Many gene sequences in eukaryotic genomes encode entire proteins or large segments of
proteins that lack a well-structured three-dimensional fold. Disordered regions can be highly …

The regulation of angiogenesis by hypoxia is an important component of homeostatic
mechanisms that link vascular oxygen supply to metabolic demand. Molecular …

There have been significant advances in our understanding of mononuclear nonheme iron
oxygenases since our 1996 Chemical Reviews article, 1 promoted in large part by the many …

The transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen
homeostasis in animals ranging from nematode worms to man. Recent studies have shown …

Covalent modification of histones has an important role in regulating chromatin dynamics
and transcription. Whereas most covalent histone modifications are reversible, until recently …

In this review, we discuss recent advances made on histone methylation and its diverse
functions in regulating gene expression. Methylation of histone polypeptides might be static …

Mutations in isocitrate dehydrogenases (IDHs) have a gain‐of‐function effect leading to R
(−)‐2‐hydroxyglutarate (R‐2HG) accumulation. By using biochemical, structural and cellular …

Histone methylation has important roles in regulating gene expression and forms part of the
epigenetic memory system that regulates cell fate and identity. Enzymes that directly remove …

Studies of the regulation of erythropoietin (EPO) production by the liver and kidneys, one of
the classical physiological responses to hypoxia, led to the discovery of human oxygen …

Fe (II)/α-ketoglutarate (αKG)-dependent hydroxylases catalyze an amazing diversity of
reactions that result in protein side-chain modifications, repair of alkylated DNA/RNA …