Bidirectional relationships of comorbidity with obstructive sleep apnoea

M Gleeson, WT McNicholas - European respiratory review, 2022‏ - Eur Respiratory Soc
Obstructive sleep apnoea (OSA) is frequently associated with comorbidities that include
metabolic, cardiovascular, renal, pulmonary and neuropsychiatric. There is considerable …

Obstructive sleep apnea and comorbidities: a dangerous liaison

MR Bonsignore, P Baiamonte, E Mazzuca… - Multidisciplinary …, 2019‏ - Springer
Obstructive sleep apnea (OSA) is a highly prevalent disease, and is traditionally associated
with increased cardiovascular risk. The role of comorbidities in OSA patients has emerged …

Obstructive sleep apnea: transition from pathophysiology to an integrative disease model

WT McNicholas, D Pevernagie - Journal of sleep research, 2022‏ - Wiley Online Library
Obstructive sleep apnea (OSA) is characterised by recurring episodes of upper airway
obstruction during sleep and the fundamental abnormality reflects the inability of the upper …

Obesity-related kidney disease: Beyond hypertension and insulin-resistance

T Arabi, A Shafqat, BN Sabbah, NA Fawzy… - Frontiers in …, 2023‏ - frontiersin.org
Chronic kidney disease (CKD) causes considerable morbidity, mortality, and health
expenditures worldwide. Obesity is a significant risk factor for CKD development, partially …

The role of SDF-1-CXCR4/CXCR7 axis in the therapeutic effects of hypoxia-preconditioned mesenchymal stem cells for renal ischemia/reperfusion injury

H Liu, S Liu, Y Li, X Wang, W Xue, G Ge, X Luo - PloS one, 2012‏ - journals.plos.org
In vitro hypoxic preconditioning (HP) of mesenchymal stem cells (MSCs) could ameliorate
their viability and tissue repair capabilities after transplantation into the injured tissue …

Hypoxia: the force that drives chronic kidney disease

Q Fu, SP Colgan, CS Shelley - Clinical medicine & research, 2016‏ - Marshfield Clinic
In the United States the prevalence of end-stage renal disease (ESRD) reached epidemic
proportions in 2012 with over 600,000 patients being treated. The rates of ESRD among the …

Declining kidney function increases the prevalence of sleep apnea and nocturnal hypoxia

DDM Nicholl, SB Ahmed, AHS Loewen… - Chest, 2012‏ - Elsevier
Background Sleep apnea is an important comorbidity in patients with chronic kidney disease
(CKD) and end-stage renal disease (ESRD). Although the increased prevalence of sleep …

Obstructive sleep apnea and kidney disease: a potential bidirectional relationship?

B Abuyassin, K Sharma, NT Ayas… - Journal of Clinical Sleep …, 2015‏ - jcsm.aasm.org
Chronic kidney disease (CKD) is associated with high mortality rates and heavy economic
and social burdens. Nearly 10% of the United States population suffer from CKD, with fatal …

Sleep apnea and chronic kidney disease: a state-of-the-art review

CH Lin, RC Lurie, OD Lyons - Chest, 2020‏ - Elsevier
Patients with chronic kidney disease have increased morbidity and mortality, mainly due to
cardiovascular disease. Compared with the general population, patients with chronic kidney …

Evaluation of continuous positive airway pressure therapy on renin–angiotensin system activity in obstructive sleep apnea

DDM Nicholl, PJ Hanly, MJ Poulin… - American journal of …, 2014‏ - atsjournals.org
Rationale: Obstructive sleep apnea (OSA) has been associated with kidney function loss,
which may be related to changes in the renin–angiotensin system (RAS). Objectives: We …