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Principles of nanoparticle formation by flash nanoprecipitation
Rapid precipitation is an efficient approach for engineering materials at the nanoscale. By
controlling solute nucleation and growth rates in solvent precipitation processes, the size of …
controlling solute nucleation and growth rates in solvent precipitation processes, the size of …
Liquid antisolvent precipitation and stabilization of nanoparticles of poorly water soluble drugs in aqueous suspensions: Recent developments and future perspective
The liquid antisolvent (LAS) precipitation process for production of ultra-fine particles has
been widely researched for a last few decades. In LAS process, precipitation of solute is …
been widely researched for a last few decades. In LAS process, precipitation of solute is …
Evading immune cell uptake and clearance requires PEG grafting at densities substantially exceeding the minimum for brush conformation
Q Yang, SW Jones, CL Parker… - Molecular …, 2014 - ACS Publications
Coating nanoparticles with polyethylene glycol (PEG), which reduces particle uptake and
clearance by immune cells, is routinely used to extend the circulation times of nanoparticle …
clearance by immune cells, is routinely used to extend the circulation times of nanoparticle …
Assessment of PEG on polymeric particles surface, a key step in drug carrier translation
Injectable drug nanocarriers have greatly benefited in their clinical development from the
addition of a superficial hydrophilic corona to improve their cargo pharmacokinetics. The …
addition of a superficial hydrophilic corona to improve their cargo pharmacokinetics. The …
Flash nanoprecipitation of polystyrene nanoparticles
Aside from polymerization techniques, polymer nanoparticles can be generated through the
displacement of a solvent with a nonsolvent, ie, nanoprecipitation. In this study, we utilize a …
displacement of a solvent with a nonsolvent, ie, nanoprecipitation. In this study, we utilize a …
Flash nanoprecipitation for the encapsulation of hydrophobic and hydrophilic compounds in polymeric nanoparticles
CE Markwalter, RF Pagels, BK Wilson… - Journal of Visualized …, 2019 - app.jove.com
The formulation of a therapeutic compound into nanoparticles (NPs) can impart unique
properties. For poorly water-soluble drugs, NP formulations can improve bioavailability and …
properties. For poorly water-soluble drugs, NP formulations can improve bioavailability and …
[HTML][HTML] Preparation and cellular uptake behaviors of uniform fiber-like micelles with length controllability and high colloidal stability in aqueous media
Fragmentation/disassembly of fiber-like micelles generated by living crystalline-driven self-
assembly (CDSA) is usually encountered in aqueous media, which hinders the applications …
assembly (CDSA) is usually encountered in aqueous media, which hinders the applications …
Cisplatin-tethered gold nanoparticles that exhibit enhanced reproducibility, drug loading, and stability: a step closer to pharmaceutical approval?
Gold nanoparticles (AuNPs) can be used as delivery vehicles for platinum anticancer drugs,
improving their targeting and uptake into cells. Here, we examine the appropriateness of …
improving their targeting and uptake into cells. Here, we examine the appropriateness of …
Effects of block copolymer properties on nanocarrier protection from in vivo clearance
Drug nanocarrier clearance by the immune system must be minimized to achieve targeted
delivery to pathological tissues. There is considerable interest in finding in vitro tests that can …
delivery to pathological tissues. There is considerable interest in finding in vitro tests that can …
Formation of Stable Nanocarriers by in Situ Ion Pairing during Block-Copolymer-Directed Rapid Precipitation
NM Pinkerton, A Grandeury, A Fisch… - Molecular …, 2013 - ACS Publications
We present an in situ hydrophobic salt forming technique for the encapsulation of weakly
hydrophobic, ionizable active pharmaceutical ingredients (API) into stable nanocarriers …
hydrophobic, ionizable active pharmaceutical ingredients (API) into stable nanocarriers …