Principles of nanoparticle formation by flash nanoprecipitation

WS Saad, RK Prud'homme - Nano Today, 2016 - Elsevier
Rapid precipitation is an efficient approach for engineering materials at the nanoscale. By
controlling solute nucleation and growth rates in solvent precipitation processes, the size of …

Liquid antisolvent precipitation and stabilization of nanoparticles of poorly water soluble drugs in aqueous suspensions: Recent developments and future perspective

AA Thorat, SV Dalvi - Chemical Engineering Journal, 2012 - Elsevier
The liquid antisolvent (LAS) precipitation process for production of ultra-fine particles has
been widely researched for a last few decades. In LAS process, precipitation of solute is …

Evading immune cell uptake and clearance requires PEG grafting at densities substantially exceeding the minimum for brush conformation

Q Yang, SW Jones, CL Parker… - Molecular …, 2014 - ACS Publications
Coating nanoparticles with polyethylene glycol (PEG), which reduces particle uptake and
clearance by immune cells, is routinely used to extend the circulation times of nanoparticle …

Assessment of PEG on polymeric particles surface, a key step in drug carrier translation

JM Rabanel, P Hildgen, X Banquy - Journal of Controlled Release, 2014 - Elsevier
Injectable drug nanocarriers have greatly benefited in their clinical development from the
addition of a superficial hydrophilic corona to improve their cargo pharmacokinetics. The …

Flash nanoprecipitation of polystyrene nanoparticles

C Zhang, VJ Pansare, RK Prud'Homme, RD Priestley - Soft Matter, 2012 - pubs.rsc.org
Aside from polymerization techniques, polymer nanoparticles can be generated through the
displacement of a solvent with a nonsolvent, ie, nanoprecipitation. In this study, we utilize a …

Flash nanoprecipitation for the encapsulation of hydrophobic and hydrophilic compounds in polymeric nanoparticles

CE Markwalter, RF Pagels, BK Wilson… - Journal of Visualized …, 2019 - app.jove.com
The formulation of a therapeutic compound into nanoparticles (NPs) can impart unique
properties. For poorly water-soluble drugs, NP formulations can improve bioavailability and …

[HTML][HTML] Preparation and cellular uptake behaviors of uniform fiber-like micelles with length controllability and high colloidal stability in aqueous media

J Ma, C Ma, X Huang, PHH de Araujo, AK Goyal… - Fundamental …, 2023 - Elsevier
Fragmentation/disassembly of fiber-like micelles generated by living crystalline-driven self-
assembly (CDSA) is usually encountered in aqueous media, which hinders the applications …

Cisplatin-tethered gold nanoparticles that exhibit enhanced reproducibility, drug loading, and stability: a step closer to pharmaceutical approval?

GE Craig, SD Brown, DA Lamprou, D Graham… - Inorganic …, 2012 - ACS Publications
Gold nanoparticles (AuNPs) can be used as delivery vehicles for platinum anticancer drugs,
improving their targeting and uptake into cells. Here, we examine the appropriateness of …

Effects of block copolymer properties on nanocarrier protection from in vivo clearance

SM D'Addio, W Saad, SM Ansell, JJ Squiers… - Journal of Controlled …, 2012 - Elsevier
Drug nanocarrier clearance by the immune system must be minimized to achieve targeted
delivery to pathological tissues. There is considerable interest in finding in vitro tests that can …

Formation of Stable Nanocarriers by in Situ Ion Pairing during Block-Copolymer-Directed Rapid Precipitation

NM Pinkerton, A Grandeury, A Fisch… - Molecular …, 2013 - ACS Publications
We present an in situ hydrophobic salt forming technique for the encapsulation of weakly
hydrophobic, ionizable active pharmaceutical ingredients (API) into stable nanocarriers …