The crucial differences between normal cells and cancer cells stem from discrete changes in
specific genes controlling proliferation and tissue homeostasis. Over 100 such cancer …

Breast cancer poses a serious public health problem, and it is hoped that identification of
genetic and environmental factors that contribute to the development of breast cancer will …

The entire coding sequence of the p53 gene was analysed for the presence of mutations in
12 families conforming to a restricted definition of Li-Fraumeni syndrome (classic LFS) and …

In 1969, a remarkable cancer predisposition syndrome was reported by Li and Fraumeni.
Using a classical epidemiologic approach, they retrospectively evaluated 280 medical …

The spectrum and frequency of cancers associated with germline TP53 mutations are
uncertain. To address this issue a cohort of individuals from 28 families with Li-Fraumeni …

Studies investigating the relationship between common genetic variants and cancer risk are
being reported with rapidly increasing frequency. We have identified 46 published case …

There are now reports of nearly 250 independent germline TP53 (p53) mutations in over
100 publications. Such mutations are typically associated with Li‐Fraumeni or Li‐Fraumeni …

The past two decades have brought many important advances in our understanding of the
hereditary susceptibility to cancer. Approximately 5–10% of all cancers are inherited, the …

Six genes confer a high risk for develo** breast cancer (BRCA1/2, TP53, PTEN, STK11,
CDH1). Both BRCA1 and BRCA2 have DNA repair functions, and BRCA1/2 deficient tumors …

Worldwide, breast cancer is the leading cause of cancer-related deaths in women. Breast
cancer is a heterogeneous disease characterized by different clinical outcomes in terms of …