Linking cell mechanical memory and cancer metastasis

E Cambria, MF Coughlin, MA Floryan… - Nature Reviews …, 2024‏ - nature.com
Metastasis causes most cancer-related deaths; however, the efficacy of anti-metastatic drugs
is limited by incomplete understanding of the biological mechanisms that drive metastasis …

Bridging the gap between tumor-on-chip and clinics: a systematic review of 15 years of studies

C Bouquerel, A Dubrova, I Hofer, DTT Phan… - Lab on a Chip, 2023‏ - pubs.rsc.org
Over the past 15 years, the field of oncology research has witnessed significant progress in
the development of new cell culture models, such as tumor-on-chip (ToC) systems. In this …

[HTML][HTML] Cancer-on-a-chip: Models for studying metastasis

X Zhang, M Karim, MM Hasan, J Hooper, R Wahab… - Cancers, 2022‏ - mdpi.com
Simple Summary Microfluidic-based cancer-on-a-chip models are powerful tools to study the
tumor microenvironment (TME). Two-dimensional cell culture cannot recapitulate TME. In …

Endothelium and subendothelial matrix mechanics modulate cancer cell transendothelial migration

Y Javanmardi, A Agrawal, A Malandrino… - Advanced …, 2023‏ - Wiley Online Library
Cancer cell extravasation, a key step in the metastatic cascade, involves cancer cell arrest
on the endothelium, transendothelial migration (TEM), followed by the invasion into the …

[HTML][HTML] Mechanical studies of the third dimension in cancer: From 2D to 3D model

F Paradiso, S Serpelloni, LW Francis… - International Journal of …, 2021‏ - mdpi.com
From the development of self-aggregating, scaffold-free multicellular spheroids to the
inclusion of scaffold systems, 3D models have progressively increased in complexity to …

Recent advances in cancer-on-a-chip tissue models to dissect the tumour microenvironment

K Seaman, Y Sun, L You - Med-X, 2023‏ - Springer
Three-dimensional cancer-on-a-chip tissue models aim to replicate the key hallmarks of the
tumour microenvironment and allow for the study of dynamic interactions that occur during …

Recent advances in vascularized tumor-on-a-chip

CBX Huang, TY Tu - Frontiers in Oncology, 2023‏ - frontiersin.org
The vasculature plays a critical role in cancer progression and metastasis, representing a
pivotal aspect in the creation of cancer models. In recent years, the emergence of organ-on …

A Versatile Microfluidic Platform for Extravasation Studies Based on DNA Origami—Cell Interactions

M García‐Chamé, P Wadhwani, J Pfeifer… - Angewandte …, 2024‏ - Wiley Online Library
The adhesion of circulating tumor cells (CTCs) to the endothelial lumen and their
extravasation to surrounding tissues are crucial in the seeding of metastases and remain the …

In vitro models of blood and lymphatic vessels—connecting tissues and immunity

A Bogseth, A Ramirez, E Vaughan… - Advanced biology, 2023‏ - Wiley Online Library
Blood and lymphatic vessels are regulators of physiological processes, including
oxygenation and fluid transport. Both vessels are ubiquitous throughout the body and are …

Cell mechanics regulate the migration and invasion of hepatocellular carcinoma cells via JNK signaling

J Wang, B Zhang, X Chen, Y **n, K Li, C Zhang… - Acta biomaterialia, 2024‏ - Elsevier
Hepatocellular carcinoma (HCC) cells, especially those with metastatic competence, show
reduced stiffness compared to the non-malignant counterparts. However, it is still unclear …