An estimated 95 million people worldwide are affected by cataract. Cataract still remains the
leading cause of blindness in middle-income and low-income countries. With the …

Small heat shock proteins (sHsps) are a ubiquitous and ancient family of ATP-independent
molecular chaperones. A key characteristic of sHsps is that they exist in ensembles of iso …

Using artificial intelligence (AI) to prevent and treat diseases is an ultimate goal in
computational medicine. Although AI has been developed for screening and assisted …

Cataract, a clouding of the lens, is the most common cause of blindness in the world. It has a
marked impact on the wellbeing and productivity of individuals and has a major economic …

The crystalline lens is a transparent and refractive biconvex structure formed by lens
epithelial cells (LECs) and lens fibers. Lens opacity, also known as cataracts, is the leading …

There are more than 100 recognized disorders of the eye. This makes the development of
advanced ocular formulations an important topic in pharmaceutical science. One of the ways …

The crystalline lens plays an important role in the refractive vision of vertebrates by
facilitating variable fine focusing of light onto the retina. Loss of lens transparency, or …

Background & Aims Three-dimensional organoid culture has fundamentally changed the in
vitro study of intestinal biology enabling novel assays; however, its use is limited because of …

Misfolding, aggregation, and aberrant accumulation of proteins are central components in
the progression of neurodegenerative disease. Cellular molecular chaperone systems …

Background Cataract is the world's leading eye disease that causes blindness. The
prevalence of cataract aged 40 years and older is approximately 11.8%–18.8%. Currently …