Despite their diverse biochemical characteristics and functions, all DNA-binding proteins
share the ability to accurately locate their target sites among the vast excess of non-target …

Visualizing and quantifying molecular motion and interactions inside living cells provides
crucial insight into the mechanisms underlying cell function. This has been achieved by …

DNA mismatch repair (MMR), the guardian of the genome, commences when MutS identifies
a mismatch and recruits MutL to nick the error-containing strand, allowing excision and DNA …

DNA replication is a fundamental process in the cell on which the functioning of the entire
cell as well as the maintenance of the entire species depends. This process is synchronized …

A series of novel unique structural organophosphorus aminopyrimidines were developed as
potential DNA-targeting membrane active inhibitors through an efficient one-pot procedure …

The emerging and development of green chemistry has once again drawn the researchers'
attention to eliminating the use and generation of hazardous materials. Here we report the …

Abstract 3D single-molecule tracking microscopy has enabled measurements of protein
diffusion in living cells, offering information about protein dynamics and cellular …

The ability to detect individual fluorescent molecules inside living cells has enabled a range
of powerful microscopy techniques that resolve biological processes on the molecular scale …

DNA replication in cells occurs on crowded and often damaged template DNA, forming
potentially deleterious roadblocks to the progressing replication fork. Numerous tools have …

Background Acinetobacter baylyi ADP1 is an ideal bacterial strain for high-throughput
genetic analysis as the bacterium is naturally transformable. Thus, ADP1 can be used to …