Tremendous progress has been made since Neuron published our Primer on genetic
dissection of neural circuits 10 years ago. Since then, cell-type-specific anatomical …

One of the holy grails of neuroscience is to record the activity of every neuron in the brain
while an animal moves freely and performs complex behavioral tasks. While important steps …

Whole-brain recordings give us a global perspective of the brain in action. In this study, we
describe a method using light field microscopy to record near-whole brain calcium and …

Defocus blur often degrades the performance of image understanding, such as object
recognition and image segmentation. Restoring an all-in-focus image from its defocused …

Significance: Light-field microscopy (LFM) enables high signal-to-noise ratio (SNR) and light
efficient volume imaging at fast frame rates. Voltage imaging with genetically encoded …

We present a novel deep learning approach to reconstruct confocal microscopy stacks from
single light field images. To perform the reconstruction, we introduce LFMNet, a fully …

Optical means for modulating and monitoring neuronal activity, have provided substantial
insights to neurophysiology and toward our understanding of how the brain works …

Recording neural activities over large populations is critical for a better understanding of the
functional mechanisms of animal brains. Traditional optical imaging technologies for in vivo …