Search and sequence analysis tools services from EMBL-EBI in 2022

F Madeira, M Pearce, ARN Tivey… - Nucleic acids …, 2022 - academic.oup.com
The EMBL-EBI search and sequence analysis tools frameworks provide integrated access to
EMBL-EBI's data resources and core bioinformatics analytical tools. EBI Search …

Rfam 14: expanded coverage of metagenomic, viral and microRNA families

I Kalvari, EP Nawrocki… - Nucleic Acids …, 2021 - academic.oup.com
Rfam is a database of RNA families where each of the 3444 families is represented by a
multiple sequence alignment of known RNA sequences and a covariance model that can be …

tRNAscan-SE 2.0: improved detection and functional classification of transfer RNA genes

PP Chan, BY Lin, AJ Mak, TM Lowe - Nucleic acids research, 2021 - academic.oup.com
Abstract tRNAscan-SE has been widely used for transfer RNA (tRNA) gene prediction for
over twenty years, developed just as the first genomes were decoded. With the massive …

Thoughts on how to think (and talk) about RNA structure

Q Vicens, JS Kieft - Proceedings of the National Academy of …, 2022 - National Acad Sciences
Recent events have pushed RNA research into the spotlight. Continued discoveries of RNA
with unexpected diverse functions in healthy and diseased cells, such as the role of RNA as …

trRosettaRNA: automated prediction of RNA 3D structure with transformer network

W Wang, C Feng, R Han, Z Wang, L Ye, Z Du… - Nature …, 2023 - nature.com
RNA 3D structure prediction is a long-standing challenge. Inspired by the recent
breakthrough in protein structure prediction, we developed trRosettaRNA, an automated …

RNAcentral 2021: secondary structure integration, improved sequence search and new member databases

Nucleic acids research, 2021 - academic.oup.com
RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences that
provides a single access point to 44 RNA resources and> 18 million ncRNA sequences from …

Structures of the eukaryotic ribosome and its translational states in situ

PC Hoffmann, JP Kreysing, I Khusainov… - Nature …, 2022 - nature.com
Ribosomes translate genetic information into primary structure. During translation, various
cofactors transiently bind to the ribosome that undergoes prominent conformational and …

FlyBase: updates to the Drosophila genes and genomes database

A Öztürk-Çolak, SJ Marygold, G Antonazzo, H Attrill… - Genetics, 2024 - academic.oup.com
FlyBase (flybase. org) is a model organism database and knowledge base about Drosophila
melanogaster, commonly known as the fruit fly. Researchers from around the world rely on …

Comprehensive survey of conserved RNA secondary structures in full-genome alignment of Hepatitis C virus

S Triebel, K Lamkiewicz, N Ontiveros, B Sweeney… - Scientific Reports, 2024 - nature.com
Hepatitis C virus (HCV) is a plus-stranded RNA virus that often chronically infects liver
hepatocytes and causes liver cirrhosis and cancer. These viruses replicate their genomes …

[HTML][HTML] Targeting non-coding RNAs: Perspectives and challenges of in-silico approaches

R Rocca, K Grillone, EL Citriniti, G Gualtieri… - European Journal of …, 2023 - Elsevier
The growing information currently available on the central role of non-coding RNAs
(ncRNAs) including microRNAs (miRNAS) and long non-coding RNAs (lncRNAs) for chronic …