As direct effector cells for osteogenesis, osteoblastic cells are commonly used for evaluating
the in vitro osteogenic capacity of bone biomaterials, and the traditional biological principle …

The repair of infected bone defects is still challenging in the fields of orthopedics, oral
implantology and maxillofacial surgery. In these cases, the self-healing capacity of bone …

Hydroxyapatite (HA), the traditional bone tissue replacement material was widely used in the
clinical treatment of bone defects because of its excellent biocompatibility. However, the …

Biomaterials-based approaches to harnessing the immune and inflammatory responses to
potentiate wound healing hold important promise. Bone fracture healing is characterized by …

Research on incorporation of both growth factors and silver (Ag) into hydroxyapatite (HA)
coatings on metallic implant surfaces for enhancing osteoinductivity and antibacterial …

Ectopic bone formation is a unique biologic entity—distinct from other areas of skeletal
biology. Animal research models of ectopic bone formation most often employ rodent …

Although a promising progress has been recently accomplished in polymer science, cell
biology, immunology and biotechnology, the biocompatibility of biomaterials still remains a …

Ideal coating materials for implants should be able to induce excellent osseointegration,
which requires several important parameters, such as good bonding strength, limited …

Abstract Bone morphogenetic protein-2 (BMP-2) is a novel differentiation factor that is
capable of inducing osteoblast differentiation and bone formation, making it an attractive …

Bioactive agents have demonstrated regenerative potential for cell-free bone tissue
engineering. Nevertheless, certain challenges persist, including ineffective delivery methods …