At the base of axons sits a unique compartment called the axon initial segment (AIS). The
AIS generates and shapes the action potential before it is propagated along the axon …

At the simplest level, neurons are structured to integrate synaptic input and perform
computational transforms on that input, converting it into an action potential (AP) code. This …

Dravet syndrome is an intractable developmental and epileptic encephalopathy caused by
de novo variants in SCN1A resulting in haploinsufficiency of the voltage-gated sodium …

The axon initial segment (AIS) is a critical microdomain for action potential initiation and
implicated in the regulation of neuronal excitability during activity-dependent plasticity. While …

Multiple sclerosis (MS) is a progressive inflammatory demyelinating disease of the CNS.
Increasing evidence suggests that vulnerable neurons in MS exhibit fatal metabolic …

In most vertebrate neurons, action potentials are triggered at the distal end of the axon initial
segment (AIS). Both position and length of the AIS vary across and within neuron types, with …

The axon initial segment is a specialized compartment of the proximal axon of CNS neurons
where action potentials are initiated. However, it remains unknown whether this domain is …

The canonical view of neuronal function is that inputs are received by dendrites and somata,
become integrated in the somatodendritic compartment and upon reaching a sufficient …

Retinal ganglion cells (RGCs) are the spiking projection neurons of the eye that encode
different features of the visual environment. The circuits providing synaptic input to different …

Highlights•AIS/axon locations within neurons are highly variable.•AIS and soma are coupled
resistively.•Resistive coupling impacts synaptic integration and action potentials.• …