A coordinated interaction between osteogenesis and osteoimmune microenvironment is
essential for successful bone healing. In particular, macrophages play a central regulatory …

Because of their excellent biologically active qualities, bioactive glasses (BGs) have been
extensively used in the biomedical domain, leading to better tissue–implant interactions and …

Repair of defective hard-tissues in osteoporotic patients faces significantly challenges with
limited therapeutic options. Although biomedical cements are considered promising …

Injectable bone biomaterials like bone cement should be designed and fabricated with
certain biological criteria, which include: 1) recruitment and polarization of the macrophages …

Numerous studies have demonstrated that calcium silicate (CS) can be doped with various
trace metal elements such as strontium (Sr) or magnesium (Mg). These studies have …

Vascularized bone tissue engineering is regarded as one of the optimal treatment options
for large bone defects. The lack of angiogenic properties and unsatisfactory …

Calcium phosphate cements (CPC) are widely anticipated to be an optimum bone repair
substitute due to its satisfied biocompatibility and degradability, suitable to be used in …

Critical bone defects caused by extensive excision of malignant bone tumor and the
probability of tumor recurrence due to residual tumor cells make malignant bone tumor …

Implant loosening remains a major clinical challenge for osteoporotic patients. This is
because osteoclastic bone resorption rate is higher than osteoblastic bone formation rate in …

Osteoporosis (OP) is a major systemic bone disease leading to an imbalance in bone
homeostasis which remains a challenge in the current treatment of bone defects. Our …