Recognizing the importance of leukocyte trafficking in inflammation led to some therapeutic
breakthroughs. However, many inflammatory pathologies remain without specific therapy …

Regulatory B cells (Bregs) is a term that encompasses all B cells that act to suppress
immune responses. Bregs contribute to the maintenance of tolerance, limiting ongoing …

Immune-based therapies such as immune checkpoint inhibitors have revolutionized the
systemic treatment of various cancer types. The therapeutic application of monoclonal …

T cells discriminate between foreign and host molecules by recognizing distinct microbial
molecules, predominantly peptides and lipids,,,. Riboflavin precursors found in many …

Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …

Antigen-presenting molecules, encoded by the major histocompatibility complex (MHC) and
CD1 family, bind peptide-and lipid-based antigens, respectively, for recognition by T cells …

There are 9 million cases of active tuberculosis reported annually; however, an estimated
one-third of the world's population is infected with Mycobacterium tuberculosis and remains …

Professional antigen-presenting cells (APCs) in the skin include dendritic cells, monocytes,
and macrophages. They are highly dynamic, with the capacity to enter skin from the …

Invariant natural killer T (iNKT) cells exist in a'poised effector'state, which enables them to
rapidly produce cytokines following activation. Using a nearly monospecific T cell receptor …