Most therapeutic agents suffer from poor solubility, rapid clearance from the blood stream, a
lack of targeting, and often poor translocation ability across cell membranes. Drug/gene …

Self-amplifying RNA (saRNA) is a promising biotherapeutic tool that has been used as a
vaccine against both infectious diseases and cancer. saRNA has been shown to induce …

Oligonucleotide-based therapy has become an alternative to classical approaches in the
search of novel therapeutics involving gene-related diseases. Several mechanisms have …

Chiral enantiomeric amino acid Schiff base copper (II) complexes 1 and 2 (a and b) were
synthesized and characterized by various spectroscopic techniques (Fourier transform …

MicroRNAs are arising as the next generation of diagnostic and therapeutic tools for gene
silencing. Studies demonstrated that the miR-29 expression is decreased in Alzheimer's …

The efficiency of siRNA delivery is demonstrated to be improved by encapsulating the siRNA
within a non-viral carrier based on layer-by-layer assembly of oppositely charged …

The implementation of RNAi technology into the clinical practice has been significantly
postponing due to the issues regarding to the delivery of naked siRNA predominantly to …

Polyplexes composed of polyethyleneimine (PEI) and DNA or siRNA have attracted great
attention for their use in gene therapy. Although many physicochemical characteristics of …

Nanoparticle-mediated siRNA delivery is a promising therapeutic approach, however, the
processes required for transport of these materials across the numerous extracellular and …

The efficacy of brain therapeutics is largely hampered by the presence of the blood–brain
barrier (BBB), mainly due to the failure of most (bio) pharmaceuticals to cross it. Accordingly …