Molecular heterogeneity and immunosuppressive microenvironment in glioblastoma
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a poor
prognosis, despite surgical resection combined with radio-and chemotherapy. The major …
prognosis, despite surgical resection combined with radio-and chemotherapy. The major …
Risk factors and biomarkers of age-related macular degeneration
NG Lambert, H ElShelmani, MK Singh… - Progress in retinal and …, 2016 - Elsevier
A biomarker can be a substance or structure measured in body parts, fluids or products that
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …
can affect or predict disease incidence. As age-related macular degeneration (AMD) is the …
Complement factor H polymorphism in age-related macular degeneration
Age-related macular degeneration (AMD) is a major cause of blindness in the elderly. We
report a genome-wide screen of 96 cases and 50 controls for polymorphisms associated …
report a genome-wide screen of 96 cases and 50 controls for polymorphisms associated …
The Factor H protein family: The switchers of the complement alternative pathway
L Lucientes‐Continente… - Immunological …, 2023 - Wiley Online Library
The factor H (FH) protein family is emerging as a complex network of proteins controlling the
fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range …
fate of the complement alternative pathway (AP) and dictating susceptibility to a wide range …
Complement factor H variant increases the risk of age-related macular degeneration
Age-related macular degeneration (AMD) is a leading cause of visual impairment and
blindness in the elderly whose etiology remains largely unknown. Previous studies identified …
blindness in the elderly whose etiology remains largely unknown. Previous studies identified …
A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
GS Hageman, DH Anderson, LV Johnson… - Proceedings of the …, 2005 - pnas.org
Age-related macular degeneration (AMD) is the most frequent cause of irreversible
blindness in the elderly in developed countries. Our previous studies implicated activation of …
blindness in the elderly in developed countries. Our previous studies implicated activation of …
Age‐related macular degeneration—emerging pathogenetic and therapeutic concepts
KM Gehrs, DH Anderson, LV Johnson… - Annals of …, 2006 - Taylor & Francis
Today, the average life expectancy in developed nations is over 80 years and climbing. And
yet, the quality of life during those additional years is often significantly diminished by the …
yet, the quality of life during those additional years is often significantly diminished by the …
Age-related macular degeneration
PTVM De Jong - New England Journal of Medicine, 2006 - Mass Medical Soc
Age-Related Macular Degeneration | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
Complement control protein factor H: the good, the bad, and the inadequate
The complement system is an essential component of the innate immune system that
participates in elimination of pathogens and altered host cells and comprises an essential …
participates in elimination of pathogens and altered host cells and comprises an essential …
C3 glomerulopathy: clinicopathologic features and predictors of outcome
NR Medjeral-Thomas… - Clinical Journal of the …, 2014 - journals.lww.com
Results Eighty patients with C3 glomerulopathy were identified: 21 with DDD and 59 with
C3GN. Patients with DDD were younger, more likely to have low serum C3 levels, and more …
C3GN. Patients with DDD were younger, more likely to have low serum C3 levels, and more …