Alzheimer's disease: updated multi-targets therapeutics are in clinical and in progress
Z Sang, K Wang, J Dong, L Tang - European journal of medicinal chemistry, 2022 - Elsevier
Alzheimer's disease is a chronic and progressive brain neurodegenerative disease affecting
over 30 million people globally. Currently, no effective treatment is available due to multiple …
over 30 million people globally. Currently, no effective treatment is available due to multiple …
Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
In silico molecular docking analysis of karan** against alzheimer's and parkinson's diseases as a potential natural lead molecule for new drug design, development …
Parkinson's disease (PD) and Alzheimer's disease (AD) are neurodegenerative disorders
that have emerged as among the serious health problems of the 21st century. The …
that have emerged as among the serious health problems of the 21st century. The …
The growing concern of chlorpyrifos exposures on human and environmental health
Chlorpyrifos (CP) and its highly electrophilic intermediates are principal toxic metabolites.
The active form of CP ie chlorpyrifos oxon (CP-oxon) is responsible for both the insecticidal …
The active form of CP ie chlorpyrifos oxon (CP-oxon) is responsible for both the insecticidal …
Insights into the structure activity relationship of nitrogen-containing heterocyclics for the development of antidepressant compounds: An updated review
Abstract According to the World Health Organization (WHO), depression is a common
mental disorder and includes complex interaction between social and psychological …
mental disorder and includes complex interaction between social and psychological …
A comprehensive review of cholinesterase modeling and simulation
D De Boer, N Nguyen, J Mao, J Moore, EJ Sorin - Biomolecules, 2021 - mdpi.com
The present article reviews published efforts to study acetylcholinesterase and
butyrylcholinesterase structure and function using computer-based modeling and simulation …
butyrylcholinesterase structure and function using computer-based modeling and simulation …
Design, Synthesis, and Pharmacological Evaluation of N-Propargylated Diphenylpyrimidines as Multitarget Directed Ligands for the Treatment of Alzheimer's Disease
Alzheimer's disease (AD), a multifactorial complex neural disorder, is categorized with
progressive memory loss and cognitive impairment as main clinical features. The multitarget …
progressive memory loss and cognitive impairment as main clinical features. The multitarget …
Acetylcholinesterase and butyrylcholinesterase inhibitory activities of khellactone coumarin derivatives isolated from Peucedanum japonicum Thurnberg
JH Heo, BH Eom, HW Ryu, MG Kang, JE Park… - Scientific Reports, 2020 - nature.com
Cholinesterase (ChE) and monoamine oxidase (MAO) inhibitors have been attracted as
candidate treatments for Alzheimer's disease (AD). Fifteen khellactone-type coumarins from …
candidate treatments for Alzheimer's disease (AD). Fifteen khellactone-type coumarins from …
Pomegranate polyphenol punicalagin improves learning memory deficits, redox homeostasis, and neuroinflammation in aging mice
P Chen, F Chen, J Lei, B Zhou - Phytotherapy Research, 2023 - Wiley Online Library
Alzheimer's disease (AD) is an irreversible, progressive brain disorder characterized by loss
of memory and cognitive dysfunction in the aged. Despite remarkable advances in drug …
of memory and cognitive dysfunction in the aged. Despite remarkable advances in drug …
New isoindole‐1, 3‐dione substituted sulfonamides as potent inhibitors of carbonic anhydrase and acetylcholinesterase: Design, synthesis, and biological evaluation
Herein, a series of isoindole‐1, 3‐dione substituted sulfonamide derivatives (3, 4 a–k) were
designed, synthesized, and biologically evaluated, as inhibitors of carbonic anhydrase (CA) …
designed, synthesized, and biologically evaluated, as inhibitors of carbonic anhydrase (CA) …