Mycobacteria, including the infamous pathogen Mycobacterium tuberculosis, are high-GC
Gram-positive bacteria with a distinctive cell envelope. Although there is a typical inner …

Corynebacterium glutamicum, a Gram-positive bacterium, has been widely used for the
industrial production of amino acids, such as glutamate and lysine, for decades. Due to …

Protein translocation across the bacterial cytoplasmic membrane is an essential process
catalyzed predominantly by the Sec translocase. This system consists of the membrane …

Protein translocation across the bacterial cytoplasmic membrane is an essential process
catalyzed by the Sec translocase, which in its minimal form consists of the protein …

In addition to SecA of the general Sec system, many Gram-positive bacteria, including
mycobacteria, express SecA2, a second, transport-associated ATPase. SecA2s can be …

Approximately 20% of bacterial proteins have functions outside the cytoplasm (1).
Consequently, all bacteria possess protein export pathways that transport proteins made in …

The Sec system is present in all bacteria and responsible for the translocation of the majority
of proteins across the cytoplasmic membrane. The system consists of two principal …

ABSTRACT While SecA is the ATPase component of the major bacterial secretory (Sec)
system, mycobacteria and some Gram-positive pathogens have a second paralog, SecA2. In …

The SecA2 protein export system is critical for the virulence of Mycobacterium tuberculosis.
However, the mechanism of this export pathway remains unclear. Through a screen for …

Protein translocation and insertion into the bacterial cytoplasmic membrane are the
essential processes mediated by the Sec machinery. The core machinery is composed of …