The glymphatic pathway in neurological disorders
Background The glymphatic (glial-lymphatic) pathway is a fluid-clearance pathway identified
in the rodent brain in 2012. This pathway subserves the flow of CSF into the brain along …
in the rodent brain in 2012. This pathway subserves the flow of CSF into the brain along …
Fluid transport in the brain
The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …
wakefulness, the brain is geared fully toward processing information and behaving, while …
Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension
Flow of cerebrospinal fluid (CSF) through perivascular spaces (PVSs) in the brain is
important for clearance of metabolic waste. Arterial pulsations are thought to drive flow, but …
important for clearance of metabolic waste. Arterial pulsations are thought to drive flow, but …
Cerebrospinal fluid outflow: a review of the historical and contemporary evidence for arachnoid villi, perineural routes, and dural lymphatics
ST Proulx - Cellular and Molecular Life Sciences, 2021 - Springer
Cerebrospinal fluid (CSF) is produced by the choroid plexuses within the ventricles of the
brain and circulates through the subarachnoid space of the skull and spinal column to …
brain and circulates through the subarachnoid space of the skull and spinal column to …
The role of brain barriers in fluid movement in the CNS: is there a 'glymphatic'system?
Brain fluids are rigidly regulated to provide stable environments for neuronal function, eg,
low K+, Ca 2+, and protein to optimise signalling and minimise neurotoxicity. At the same …
low K+, Ca 2+, and protein to optimise signalling and minimise neurotoxicity. At the same …
The glymphatic system: implications for drugs for central nervous system diseases
In the past decade, evidence for a fluid clearance pathway in the central nervous system
known as the glymphatic system has grown. According to the glymphatic system concept …
known as the glymphatic system has grown. According to the glymphatic system concept …
[HTML][HTML] Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia
Loss-of-function heterozygous mutations in GRN, the gene encoding progranulin (PGRN),
were identified in patients with frontotemporal lobar degeneration (FTLD) almost two …
were identified in patients with frontotemporal lobar degeneration (FTLD) almost two …
How does the immune system enter the brain?
Multiple Sclerosis (MS) is considered the most frequent inflammatory demyelinating disease
of the central nervous system (CNS). It occurs with a variable prevalence across the world. A …
of the central nervous system (CNS). It occurs with a variable prevalence across the world. A …
[HTML][HTML] Brain-wide glymphatic enhancement and clearance in humans assessed with MRI
G Ringstad, LM Valnes, AM Dale, AH Pripp… - JCI insight, 2018 - ncbi.nlm.nih.gov
To what extent does the subarachnoid cerebrospinal fluid (CSF) compartment communicate
directly with the extravascular compartment of human brain tissue? Interconnection between …
directly with the extravascular compartment of human brain tissue? Interconnection between …
Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys
MS Kariolis, RC Wells, JA Getz, W Kwan… - Science translational …, 2020 - science.org
Effective delivery of protein therapeutics to the central nervous system (CNS) has been
greatly restricted by the blood-brain barrier (BBB). We describe the development of a BBB …
greatly restricted by the blood-brain barrier (BBB). We describe the development of a BBB …