Fluorescence‐Based HTS Assays for Ion Channel Modulation in Drug Discovery Pipelines

J Voldřich, M Matoušová, M Šmídková… - …, 2024 - Wiley Online Library
Ion channels represent a druggable family of transmembrane pore‐forming proteins with
important (patho) physiological functions. While electrophysiological measurement (manual …

[HTML][HTML] Elucidation of medusozoan (jellyfish) venom constituent activities using constellation pharmacology

AA Yanagihara, ML Giglio, K Hurwitz, R Kadler… - Toxins, 2024 - mdpi.com
Within the phylum Cnidaria, sea anemones (class Anthozoa) express a rich diversity of ion-
channel peptide modulators with biomedical applications, but corollary discoveries from …

NeuriteNet: A convolutional neural network for assessing morphological parameters of neurite growth

JT Vecchi, S Mullan, JA Lopez, MR Hansen… - Journal of neuroscience …, 2021 - Elsevier
Background During development or regeneration, neurons extend processes (ie., neurites)
via mechanisms that can be readily analyzed in culture. However, defining the impact of a …

Deep Learning and Explainable AI in Medical Image Segmentation

S Mullan - 2023 - search.proquest.com
Medical imaging is a critical part of modern healthcare, and the continued advancement of
imaging techniques have enabled the analysis of an every growing number of objects and …

[PDF][PDF] Deep learning and explainable AI in medical imaging

S Mullan - 2023 - iro.uiowa.edu
Medical imaging is a critical part of modern healthcare, and the continued advancement of
imaging techniques have enabled the analysis of an every growing number of objects and …

Characterization of Calcium binding protein 1 (CaBP1/Caldendrin) expression and function in dorsal root ganglion neurons

JA Lopez - 2021 - search.proquest.com
The dorsal root ganglion (DRG) is a cluster of heterogenous neurons that are responsible for
transmitting sensory input signals such as touch, pain, and temperature from the periphery to …

NeuriteNet: A Convolutional Neural Network for determining morphological differences in neurite growth

J Vecchi, S Mullan, J Lopez, MR Hansen, M Sonka… - bioRxiv, 2021 - biorxiv.org
Background During development or regeneration, neurons extend processes (ie, neurites)
via mechanisms that can be readily analyzed in culture. However, defining the impact of a …