Despite their relative simplicity, iron–sulfur clusters have been omnipresent as cofactors in
myriad cellular processes such as oxidative phosphorylation and other respiratory …

Herpesviruses are major pathogens that infect humans and animals. Manipulating the large
genome is critical for exploring the function of specific genes and studying the pathogenesis …

DNA helicases are a class of molecular motors that catalyze processive unwinding of double
stranded DNA. In spite of much study, we know relatively little about the mechanisms by …

DNA recombination repair systems are essential for organisms to maintain genomic stability.
In recent years, we have improved our understanding of the mechanisms of RecBCD/AddAB …

E. coli RecBCD, a helicase/nuclease involved in double stranded (ds) DNA break repair,
binds to a dsDNA end and melts out several DNA base pairs (bp) using only its binding free …

Current models of bacterial homologous recombination (HR) posit that extensive resection
of a DNA double-strand break (DSB) by a multisubunit helicase–nuclease machine (eg …

RecBCD enzyme is a complex, three-subunit protein machine essential for the major
pathway of DNA double-strand break repair and homologous recombination in Escherichia …

In bacteria, double-strand break (DSB) repair via homologous recombination is thought to
be initiated through the bi-directional degradation and resection of DNA ends by a helicase …

Homologous recombination plays key roles in fundamental processes such as recovery from
DNA damage and in bacterial horizontal gene transfer, yet there are still open questions …

The adaptive immune function of CRISPR-Cas systems in bacteria and archaea is mediated
through CRISPR-Associated Proteins (Cas). The adaptation module, typically involving …