Neuroinflammation in Alzheimer disease

MT Heneka, WM van der Flier, F Jessen… - Nature Reviews …, 2024 - nature.com
Increasing evidence points to a pivotal role of immune processes in the pathogenesis of
Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing …

[HTML][HTML] Long COVID: pathophysiological factors and abnormalities of coagulation

S Turner, MA Khan, D Putrino, A Woodcock… - Trends in Endocrinology …, 2023 - cell.com
Acute COVID-19 infection is followed by prolonged symptoms in approximately one in ten
cases: known as Long COVID. The disease affects~ 65 million individuals worldwide. Many …

Transforming the understanding of brain immunity

G Castellani, T Croese, JM Peralta Ramos, M Schwartz - Science, 2023 - science.org
Contemporary studies have completely changed the view of brain immunity from envisioning
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …

Revisiting the neurovascular unit

S Schaeffer, C Iadecola - Nature neuroscience, 2021 - nature.com
The brain is supplied by an elaborate vascular network that originates extracranially and
reaches deep into the brain. The concept of the neurovascular unit provides a useful …

Insights into Alzheimer's disease from single-cell genomic approaches

MH Murdock, LH Tsai - Nature neuroscience, 2023 - nature.com
Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling …

Peripheral and central immune system crosstalk in Alzheimer disease—a research prospectus

BM Bettcher, MG Tansey, G Dorothée… - Nature Reviews …, 2021 - nature.com
Dysregulation of the immune system is a cardinal feature of Alzheimer disease (AD), and a
considerable body of evidence indicates pathological alterations in central and peripheral …

SARS CoV‐2 related microvascular damage and symptoms during and after COVID‐19: Consequences of capillary transit‐time changes, tissue hypoxia and …

L Østergaard - Physiological reports, 2021 - Wiley Online Library
Abstract Corona virus disease 2019 (COVID‐19) causes symptoms from multiple organs
after infection by severe acute respiratory syndrome corona virus 2 (SARS CoV‐2). They …

Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology

GS Gullotta, D De Feo, E Friebel, A Semerano… - Nature …, 2023 - nature.com
Aging accounts for increased risk and dismal outcome of ischemic stroke. Here, we
investigated the impact of age-related changes in the immune system on stroke. Upon …

[HTML][HTML] Alzheimer disease: an update on pathobiology and treatment strategies

JM Long, DM Holtzman - Cell, 2019 - cell.com
Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …

The neurovasculome: key roles in brain health and cognitive impairment: a scientific statement from the American Heart Association/American Stroke Association

C Iadecola, EE Smith, J Anrather, C Gu, A Mishra… - Stroke, 2023 - ahajournals.org
Background: Preservation of brain health has emerged as a leading public health priority for
the aging world population. Advances in neurovascular biology have revealed an intricate …