[HTML][HTML] Thinking outside the nucleus: Mitochondrial DNA copy number in health and disease

CA Castellani, RJ Longchamps, J Sun, E Guallar… - Mitochondrion, 2020 - Elsevier
Mitochondrial DNA copy number (mtDNA-CN) is a biomarker of mitochondrial function and
levels of mtDNA-CN have been reproducibly associated with overall mortality and a number …

Mitochondrial ROS‐Modulated mtDNA: a potential target for cardiac aging

Y Quan, Y **n, G Tian, J Zhou… - Oxidative medicine and …, 2020 - Wiley Online Library
Mitochondrial DNA (mtDNA) damage is associated with the development of cardiovascular
diseases. Cardiac aging plays a central role in cardiovascular diseases. There is …

Association of mitochondrial DNA copy number with metabolic syndrome and type 2 diabetes in 14 176 individuals

F Fazzini, C Lamina, A Raftopoulou… - Journal of Internal …, 2021 - Wiley Online Library
Background Mitochondria play an important role in cellular metabolism, and their
dysfunction is postulated to be involved in metabolic disturbances. Mitochondrial DNA is …

GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights a potential causal role in dementia

M Chong, P Mohammadi-Shemirani, N Perrot… - Elife, 2022 - elifesciences.org
GWAS and ExWAS of blood mitochondrial DNA copy number identifies 71 loci and highlights
a potential causal role in dementia | eLife Skip to Content eLife logo eLife home page Menu …

Associations of mitochondrial and nuclear mitochondrial variants and genes with seven metabolic traits

AT Kraja, C Liu, JL Fetterman, M Graff, CT Have… - The American Journal of …, 2019 - cell.com
Mitochondria (MT), the major site of cellular energy production, are under dual genetic
control by 37 mitochondrial DNA (mtDNA) genes and numerous nuclear genes (MT-nDNA) …

Targeted Magnetic Resonance Imaging/Near‐Infrared Dual‐Modal Imaging and Ferroptosis/Starvation Therapy of Gastric Cancer with Peritoneal Metastasis

W Guo, Y Ren, Z Chen, G Shen, Y Lu… - Advanced Functional …, 2023 - Wiley Online Library
Accurate identification and visualization of peritoneal metastases (PM) are clinically
essential to improving the prognosis for gastric cancer. However, owing to the multifocal …

Cell-free circulating mitochondrial DNA: An emerging biomarker for airborne particulate matter associated with cardiovascular diseases

A Rehman, R Kumari, A Kamthan, R Tiwari… - Free Radical Biology …, 2023 - Elsevier
The association of airborne particulate matter exposure with the deteriorating function of the
cardiovascular system is fundamentally driven by the impairment of mitochondrial-nuclear …

Association between mitochondrial DNA copy number and cardiovascular disease: Current evidence based on a systematic review and meta-analysis

P Yue, S **g, L Liu, F Ma, Y Zhang, C Wang, H Duan… - PloS one, 2018 - journals.plos.org
Background Mitochondria are energy-producing structure of the cell and help to maintain
redox environment. In cardiovascular disease, the number of mitochondrial DNA (mtDNA) …

Peripheral blood mitochondrial DNA levels were modulated by SARS-CoV-2 infection severity and its lessening was associated with mortality among hospitalized …

JJ Valdés-Aguayo, I Garza-Veloz… - Frontiers in Cellular …, 2021 - frontiersin.org
Introduction During severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection, the virus hijacks the mitochondria causing damage of its membrane and release of …

Mitochondria as novel mediators linking gut microbiota to atherosclerosis that is ameliorated by herbal medicine: A review

Y Li, S Yang, X **, D Li, J Lu, X Wang… - Frontiers in …, 2023 - frontiersin.org
Atherosclerosis (AS) is the main cause of cardiovascular disease (CVD) and is
characterized by endothelial damage, lipid deposition, and chronic inflammation. Gut …