A dense and diverse array of glycans on glycoproteins and glycolipids decorate all cell
surfaces. In vertebrates, many of these carry sialic acid, in a variety of linkages and glycan …

Siglecs (sialic acid-binding immunoglobulin-like lectins) are a family of vertebrate glycan-
binding cell-surface proteins. The majority mediate cellular inhibitory activity once engaged …

IgG secreted by B cells carry asparagine N (297)-linked glycans in the fragment
crystallizable (Fc) region. Changes in Fc glycosylation are related to health or disease and …

CD22 and Siglec-G are members of the Siglec family. Both are inhibitory co-receptors on the
surface of B cells and inhibit B-cell receptor induced signaling, characterized by inhibition of …

Post-translational modifications (PTMs) immensely expand the diversity of the proteome.
Glycosylation, among the most ubiquitous PTMs, is a dynamic and multifarious modification …

The protein tyrosine phosphatase CD45 plays a crucial role in B cell antigen receptor (BCR)
signaling by activating Src family kinases. Cd45−/− mice show altered B cell development …

Glycosylation is a ubiquitous post-translational modification read by glycan-binding proteins
(GBP) to encode important functions, but a robust understanding of these interactions and …

B cells express various inhibitory co-receptors including CD22, CD72, and Siglec-G. These
receptors contain immunoreceptor tyrosine-based inhibition motifs (ITIMs) in the cytoplasmic …

CD22 (also known as Siglec-2) is an inhibitory receptor expressed in B cells. CD22
specifically recognizes α2, 6 sialic acid and interacts with α2, 6 sialylated membrane …

Glycans play a pivotal role in biology. However, because of the low-affinity of glycan-protein
interactions, many interaction pairs remain unknown. Two important glycoproteins involved …