Antimalarial drug discovery: Progress and approaches
Recent antimalarial drug discovery has been a race to produce new medicines that
overcome emerging drug resistance, whilst considering safety and improving dosing …
overcome emerging drug resistance, whilst considering safety and improving dosing …
Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic
B Blasco, D Leroy, DA Fidock - Nature medicine, 2017 - nature.com
The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …
Beyond PI3Ks: targeting phosphoinositide kinases in disease
Lipid phosphoinositides are master regulators of almost all aspects of a cell's life and death
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …
and are generated by the tightly regulated activity of phosphoinositide kinases. Although …
Drugs in development for malaria
The last two decades have seen a surge in antimalarial drug development with product
development partnerships taking a leading role. Resistance of Plasmodium falciparum to the …
development partnerships taking a leading role. Resistance of Plasmodium falciparum to the …
Structural basis for regulation of phosphoinositide kinases and their involvement in human disease
JE Burke - Molecular cell, 2018 - cell.com
Lipid phosphoinositides play fundamental roles in virtually all pathways that control a cell's
decision to grow, move, divide, and die. Because of this, kinases that phosphorylate …
decision to grow, move, divide, and die. Because of this, kinases that phosphorylate …
Challenges and recent progress in drug discovery for tropical diseases
Infectious tropical diseases have a huge effect in terms of mortality and morbidity, and
impose a heavy economic burden on affected countries. These diseases predominantly …
impose a heavy economic burden on affected countries. These diseases predominantly …
Novel roles of phosphoinositides in signaling, lipid transport, and disease
Phosphoinositides (PPIns) are lipid signaling molecules that act as master regulators of
cellular signaling. Recent studies have revealed novel roles of PPIns in myriad cellular …
cellular signaling. Recent studies have revealed novel roles of PPIns in myriad cellular …
Current development of 1, 2, 3-triazole derived potential antimalarial scaffolds: Structure activity relationship (SAR) and bioactive compounds
Malaria is among one of the most devastating and deadliest parasitic disease in the world
claiming millions of lives every year around the globe. It is a mosquito-borne infectious …
claiming millions of lives every year around the globe. It is a mosquito-borne infectious …
[HTML][HTML] First fully-automated AI/ML virtual screening cascade implemented at a drug discovery centre in Africa
Streamlined data-driven drug discovery remains challenging, especially in resource-limited
settings. We present ZairaChem, an artificial intelligence (AI)-and machine learning (ML) …
settings. We present ZairaChem, an artificial intelligence (AI)-and machine learning (ML) …
Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials
M Duffey, B Blasco, JN Burrows, TNC Wells… - Trends in …, 2021 - cell.com
Strategies to counteract or prevent emerging drug resistance are crucial for the design of
next-generation antimalarials. In the past, resistant parasites were generally identified …
next-generation antimalarials. In the past, resistant parasites were generally identified …