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Strategies of organic phosphorus recycling by soil bacteria: acquisition, metabolism, and regulation
Critical to meeting cellular phosphorus (P) demand, soil bacteria deploy a number of
strategies to overcome limitation in inorganic P (Pi) in soils. As a significant contributor to P …
strategies to overcome limitation in inorganic P (Pi) in soils. As a significant contributor to P …
[HTML][HTML] The structural basis of secondary active transport mechanisms
Secondary active transporters couple the free energy of the electrochemical potential of one
solute to the transmembrane movement of another. As a basic mechanistic explanation for …
solute to the transmembrane movement of another. As a basic mechanistic explanation for …
[HTML][HTML] Three-dimensional structures of membrane proteins from genomic sequencing
We show that amino acid covariation in proteins, extracted from the evolutionary sequence
record, can be used to fold transmembrane proteins. We use this technique to predict …
record, can be used to fold transmembrane proteins. We use this technique to predict …
Ins and outs of major facilitator superfamily antiporters
The major facilitator superfamily (MFS) represents the largest group of secondary active
membrane transporters, and its members transport a diverse range of substrates. Recent …
membrane transporters, and its members transport a diverse range of substrates. Recent …
Molecular mechanisms and clinical impact of acquired and intrinsic fosfomycin resistance
Bacterial infections caused by antibiotic-resistant isolates have become a major health
problem in recent years, since they are very difficult to treat, leading to an increase in …
problem in recent years, since they are very difficult to treat, leading to an increase in …
Functional characterization of the rice SPX‐MFS family reveals a key role of OsSPX‐MFS1 in controlling phosphate homeostasis in leaves
Proteins possessing the SPX domain are found in several proteins involved in inorganic
phosphate (Pi) transport and signalling in yeast and plants. Although the functions of several …
phosphate (Pi) transport and signalling in yeast and plants. Although the functions of several …
Fosfomycin resistance mechanisms in Enterobacterales: an increasing threat
Antimicrobial resistance is well-known to be a global health and development threat. Due to
the decrease of effective antimicrobials, re-evaluation in clinical practice of old antibiotics, as …
the decrease of effective antimicrobials, re-evaluation in clinical practice of old antibiotics, as …
Flip** lipids: why an'what's the reason for?
The biosynthesis of glycoconjugates such as N-glycoproteins and GPI-anchored proteins in
eukaryotes and cell wall peptidoglycan and lipopolysaccharide in bacteria requires lipid …
eukaryotes and cell wall peptidoglycan and lipopolysaccharide in bacteria requires lipid …
The Glycerol-3-Phosphate Permease GlpT Is the Only Fosfomycin Transporter in Pseudomonas aeruginosa
Fosfomycin is transported into Escherichia coli via both glycerol-3-phosphate (GlpT) and a
hexose phosphate transporter (UhpT). Consequently, the inactivation of either glpT or uhpT …
hexose phosphate transporter (UhpT). Consequently, the inactivation of either glpT or uhpT …
Uncoupling and turnover in a Cl−/H+ exchange transporter
The CLC-family protein CLC-ec1, a bacterial homologue of known structure,
stoichiometrically exchanges two Cl− for one H+ via an unknown membrane transport …
stoichiometrically exchanges two Cl− for one H+ via an unknown membrane transport …