Vitiligo is a multifactorial polygenic disorder with a complex pathogenesis, linked with both
genetic and non‐genetic factors. The precise modus operandi for vitiligo pathogenesis has …

The PTPN22 locus is one of the strongest risk factors outside of the major histocompatability
complex that associates with autoimmune diseases. PTPN22 encodes lymphoid protein …

It is known that the etiology and clinical outcomes of autoimmune diseases are associated
with a combination of genetic and environmental factors. In the case of the genetic factor, the …

Abstract Tumor Necrosis Factor (TNF)-α, is a paracrine inhibitor of melanocytes, which plays
a critical role in the pathogenesis of several autoimmune diseases including vitiligo, as …

Epidermal melanocyte loss in vitiligo, triggered by stresses ranging from trauma to emotional
stress, chemical exposure or metabolite imbalance, to the unknown, can stimulate oxidative …

Vitiligo is a chronic stigmatizing disease, already known for millennia, which mainly affects
melanocytes from epidermis basal layer, leading to the development of hypochromic and …

Protein tyrosine phosphatase non-receptor type 22 (PTPN22) is a strong susceptibility gene
shared by many autoimmune diseases. The aim of this study was to explore the …

Vitiligo is a complex disorder in which autoimmune destruction of melanocytes results in
white patches of skin and overlying hair. Over the past several years, extensive genetic …

Background: Generalized vitiligo is an autoimmune disease of skin pigmentation that is
associated with increased prevalence of other autoimmune diseases, particularly …

Interferon-gamma (IFN-γ) is a paracrine inhibitor of melanocytes and genetic variability due
to intron 1 polymorphisms in IFNG has been reported to be associated with increased risk for …