Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …

Stress is a central concept in biology and has now been widely used in psychological,
physiological, social, and even environmental fields. However, the concept of stress was …

Anemia in astronauts has been noted since the first space missions, but the mechanisms
contributing to anemia in space flight have remained unclear. Here, we show that space …

Spaceflight can change metabolic, immunological, and biological homeostasis and cause
skin rashes and irritation, yet the molecular basis remains unclear. To investigate the impact …

Microgravity is associated with immunological dysfunction, though the mechanisms are
poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear …

The recent acceleration of commercial, private and multi-national spaceflight has created an
unprecedented level of activity in low Earth orbit, concomitant with the largest-ever number …

The field of human space travel is in the midst of a dramatic revolution. Upcoming missions
are looking to push the boundaries of space travel, with plans to travel for longer distances …

Skeletal muscle atrophy is a well-known consequence of spaceflight. Because of the
potential significant impact of muscle atrophy and muscle dysfunction on astronauts and …

Abstract The SpaceX Inspiration4 mission provided a unique opportunity to study the impact
of spaceflight on the human body. Biospecimen samples were collected from four crew …