Bacteria of the genus Legionella are natural pathogens of amoebae that can cause a severe
pneumonia in humans called Legionnaires' Disease. Human disease results from inhalation …

To prevail in the interaction with eukaryotic hosts, many bacterial pathogens use protein
secretion systems to release virulence factors at the host–pathogen interface and/or deliver …

A widespread strategy employed by pathogens to establish infection is to inhibit host-cell
protein synthesis. Legionella pneumophila, an intracellular bacterial pathogen and the …

To replicate within host cells, bacterial pathogens must acquire host-derived nutrients while
avoiding degradative antimicrobial pathways. Fundamental insights into bacterial …

Legionella pneumophila utilizes the Dot/Icm type IVB secretion system to deliver hundreds
of effector proteins inside eukaryotic cells to ensure intracellular replication. Our …

The survival of Legionella spp. as intracellular pathogens relies on the combined action of
protein effectors delivered inside their eukaryotic hosts by the Dot/Icm (d efective in o …

Legionella pneumophila uses over 300 translocated effector proteins to rewire host cells
during infection and create a replicative niche for intracellular growth. To date, several …

Many bacterial pathogens utilize translocated virulence factors called effectors to
successfully infect their host. Within the host cell, effector proteins facilitate pathogen …

The bacterial pathogen Legionella pneumophila uses effectors—toxins—to facilitate
pathogenesis within host cells. A recent study identifies dual mechanisms of the effector SidI …

Legionella is a gram-negative microorganism and an infectious agent of pneumonia in
humans. It is an intracellular pathogen and multiplies in different eukaryotic cells like …