Epithelial cells are the most common cell type in all animals, forming the sheets and tubes
that compose most organs and tissues. Apical–basal polarity is essential for epithelial cell …

Epithelia and endothelia separate different tissue compartments and protect multicellular
organisms from the outside world. This requires the formation of tight junctions, selective …

Epithelial cells require apical–basal plasma membrane polarity to carry out crucial vectorial
transport functions and cytoplasmic polarity to generate different cell progenies for tissue …

After years of extensive scientific discovery much has been learned about the networks that
regulate epithelial homeostasis. Loss of expression or functional activity of cell adhesion …

To form epithelial organs cells must polarize and generate de novo an apical domain and
lumen. Epithelial polarization is regulated by polarity complexes that are hypothesized to …

Cell polarity, the generation of cellular asymmetries, is necessary for diverse processes in
animal cells, such as cell migration, asymmetric cell division, epithelial barrier function, and …

Epithelial tissue formation and function requires the apical-basal polarization of individual
epithelial cells. Apical polarity regulators (APRs) are an evolutionarily conserved group of …

The correct establishment and maintenance of cell polarity are crucial for normal cell
physiology and tissue homeostasis. Conversely, loss of cell polarity, tissue disorganisation …

The conserved polarity effector proteins PAR-3, PAR-6, CDC-42, and atypical protein kinase
C (aPKC) form a core unit of the PAR protein network, which plays a central role in …

Abstract E-Cadherin-based Adherens Junctions (AJs) are a defining feature of all epithelial
sheets. Through the homophilic association of E-Cadherin molecules expressed on …