Historically, the genus Aloe has been an indispensable part of both traditional and modern
medicine. Decades of intensive research have unveiled the major bioactive secondary …

The inadequate vascularization seen in fast-growing solid tumors gives rise to hypoxic
areas, fostering specific changes in gene expression that bolster tumor cell survival and …

Skin injuries are one of the most common clinical traumas worldwide, and wound dressings
are considered to be one of key factors in wound healing. Natural polymer-based hydrogels …

An investigation on the secondary metabolites from a rice culture broth of the endophytic
fungus Neurospora terricola HDF-Br-2 derived from the vulnerable conifer Pseudotsuga …

An atypical nonheme iron-dependent dioxygenase BTG13 with a rare iron coordination of
four histidine residues and a carboxylated-lysine (Kcx) was recently reported to catalyze the …

Background Inflammation is a risk factor for tumorigenesis. Macrophage, a subset of immune
cells with high plasticity, plays a multifaceted role in this process. Natural products, which …

Xanthone-based polyketides with complex molecular frameworks and potent bioactivities
distribute and function in different biological kingdoms, yet their biosynthesis remains under …

To date, there are no real physiological mechanisms for iron excretion in eukaryote, and no
physiological “actuator” that can control all the three fundamental biologic processes of …

Nature uses compact but functionalized biosynthetic fragments as building blocks to
generate complex natural products. To leverage this strategy for the discovery of natural …

Background Non-reducing polyketide synthases (NR-PKSs) account for a major share of
natural product diversity produced by both Asco-and Basidiomycota. The present …