Advantages and challenges of the spray-drying technology for the production of pure drug particles and drug-loaded polymeric carriers

A Sosnik, KP Seremeta - Advances in colloid and interface science, 2015 - Elsevier
Spray-drying is a rapid, continuous, cost-effective, reproducible and scalable process for the
production of dry powders from a fluid material by atomization through an atomizer into a hot …

Unraveling particle formation: From single droplet drying to spray drying and electrospraying

E Boel, R Koekoekx, S Dedroog, I Babkin, MR Vetrano… - Pharmaceutics, 2020 - mdpi.com
Spray drying and electrospraying are well-established drying processes that already have
proven their value in the pharmaceutical field. However, there is currently still a lack of …

Particle engineering principles and technologies for pharmaceutical biologics

D Cun, C Zhang, H Bera, M Yang - Advanced Drug Delivery Reviews, 2021 - Elsevier
The global market of pharmaceutical biologics has expanded significantly during the last few
decades. Currently, pharmaceutical biologic products constitute an indispensable part of the …

Nanoparticle-mediated pulmonary drug delivery: State of the art towards efficient treatment of recalcitrant respiratory tract bacterial infections

Z Huang, SN Kłodzińska, F Wan… - Drug delivery and …, 2021 - Springer
Recalcitrant respiratory tract infections caused by bacteria have emerged as one of the
greatest health challenges worldwide. Aerosolized antimicrobial therapy is becoming …

Quality by design thinking in the development of long-acting injectable PLGA/PLA-based microspheres for peptide and protein drug delivery

C Zhang, L Yang, F Wan, H Bera, D Cun… - International journal of …, 2020 - Elsevier
Abstract Adopting the Quality by Design (QbD) approach in the drug development process
has transformed from “nice-to-do” into a crucial and required part of the development …

Inhalable nanoparticles delivery targeting alveolar macrophages for the treatment of pulmonary tuberculosis

J Chae, Y Choi, M Tanaka, J Choi - Journal of bioscience and …, 2021 - Elsevier
Pulmonary tuberculosis is a highly prevalent respiratory disease that affects approximately a
quarter of the world's population. The drug treatment protocol for tuberculosis is complex …

Characterization of amorphous solid dispersions

X Liu, X Feng, RO Williams, F Zhang - Journal of Pharmaceutical …, 2018 - Springer
The study of amorphous solid dispersions (ASDs) is currently one of the most exciting areas
in pharmaceutics. Research has shown that ASDs offer unique advantages in improving the …

Spray drying as an advantageous strategy for enhancing pharmaceuticals bioavailability

AH Salama - Drug Delivery and Translational Research, 2020 - Springer
Spray drying is an efficient technique that is used not only for rapid evaporation of the
solvent from different systems but also for designing ultra-fine particles with various …

Design of PLGA-based depot delivery systems for biopharmaceuticals prepared by spray drying

F Wan, M Yang - International journal of pharmaceutics, 2016 - Elsevier
Currently, most of the approved protein and peptide-based medicines are delivered via
conventional parenteral injection (intramuscular, subcutaneous or intravenous). A frequent …

Drying of a single droplet to investigate process–structure–function relationships: a review

C Sadek, P Schuck, Y Fallourd, N Pradeau… - Dairy Science & …, 2015 - Springer
Drying usually results in various types of particle morphology that influence the properties
and the functionality of powders. Understanding how the final shape of the particle is formed …