The mammalian circadian clock has evolved as an adaptation to the 24-h light/darkness
cycle on earth. Maintaining cellular activities in synchrony with the activities of the organism …

Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

The mammalian circadian clock involves a transcriptional feed back loop in which CLOCK
and BMAL1 activate the Period and Cryptochrome genes, which then feedback and repress …

Cancer chronotherapy, treatment at specific times during circadian rhythms, endeavors to
optimize anti-tumor effects and to lower toxicity. However, comprehensive characterization of …

Glucocorticoid (GC) is an adrenal steroid hormone that controls a variety of physiological
processes such as metabolism, immune response, cardiovascular activity, and brain …

The circadian clock in mammals regulates the sleep/wake cycle and many associated
behavioral and physiological processes. The cellular clock mechanism involves a …

The mechanistic interconnectivity between circadian regulation and the genotoxic stress
response remains poorly understood. Here we show that the expression of Period 2 (Per2) …

Abstract Background Patients with Alzheimer's disease (AD) frequently experience
disruption of their circadian rhythms, but whether and how circadian clock molecules are …

Over the last decades, researchers have characterized a set of “clock genes” that drive daily
rhythms in physiology and behavior. This arduous work has yielded results with far-reaching …

Circadian disruption has multiple pathological consequences, but the underlying
mechanisms are largely unknown. To address such mechanisms, we subjected transformed …