How cryo‐electron microscopy and X‐ray crystallography complement each other
HW Wang, JW Wang - Protein Science, 2017 - Wiley Online Library
With the ability to resolve structures of macromolecules at atomic resolution, X‐ray
crystallography has been the most powerful tool in modern structural biology. At the same …
crystallography has been the most powerful tool in modern structural biology. At the same …
The CryoEM method MicroED as a powerful tool for small molecule structure determination
In the many scientific endeavors that are driven by organic chemistry, unambiguous
identification of small molecules is of paramount importance. Over the past 50 years, NMR …
identification of small molecules is of paramount importance. Over the past 50 years, NMR …
Current trends and advancements in crystallization and single-crystal structural analysis of small molecules
The advancement of single-crystal structural analysis has emerged as a pivotal technology
surpassing spectroscopic methods in revealing the intricate structural details of organic …
surpassing spectroscopic methods in revealing the intricate structural details of organic …
Structure of the toxic core of α-synuclein from invisible crystals
The protein α-synuclein is the main component of Lewy bodies, the neuron-associated
aggregates seen in Parkinson disease and other neurodegenerative pathologies. An 11 …
aggregates seen in Parkinson disease and other neurodegenerative pathologies. An 11 …
[PDF][PDF] MicroED data collection and processing
MicroED, a method at the intersection of X-ray crystallography and electron cryo-microscopy,
has rapidly progressed by exploiting advances in both fields and has already been …
has rapidly progressed by exploiting advances in both fields and has already been …
Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED
Electrons, because of their strong interaction with matter, produce high-resolution diffraction
patterns from tiny 3D crystals only a few hundred nanometers thick in a frozen-hydrated …
patterns from tiny 3D crystals only a few hundred nanometers thick in a frozen-hydrated …
Current trends in protein crystallization
JA Gavira - Archives of biochemistry and biophysics, 2016 - Elsevier
Proteins belong to the most complex colloidal system in terms of their physicochemical
properties, size and conformational-flexibility. This complexity contributes to their great …
properties, size and conformational-flexibility. This complexity contributes to their great …
Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface
Amyloid-β (Aβ) harbors numerous posttranslational modifications (PTMs) that may affect
Alzheimer's disease (AD) pathogenesis. Here we present the 1.1 Å resolution MicroED …
Alzheimer's disease (AD) pathogenesis. Here we present the 1.1 Å resolution MicroED …
[PDF][PDF] Automated electron diffraction tomography–development and applications
Electron diffraction tomography (EDT) has gained increasing interest, starting with the
development of automated electron diffraction tomography (ADT) which enables the …
development of automated electron diffraction tomography (ADT) which enables the …
On the quality of the continuous rotation electron diffraction data for accurate atomic structure determination of inorganic compounds
The continuous rotation electron diffraction (cRED) method has the capability of providing
fast three-dimensional electron diffraction data collection on existing and future transmission …
fast three-dimensional electron diffraction data collection on existing and future transmission …