Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …

By influencing Ca2+ homeostasis in spatially and architecturally distinct neuronal
compartments, the endoplasmic reticulum (ER) illustrates the notion that form and function …

Key points The endothelium plays a pivotal role in the vascular response to chemical and
mechanical stimuli. The endothelium is exquisitely sensitive to ACh, although the …

Calcium influx can be stimulated by various intra-and extracellular signals to set coordinated
gene expression programs into motion. As such, the precise regulation of intracellular …

The process of development depends on a number of signaling systems that regulates the
progressive sequence of developmental events. Infertility and neurodevelopmental …

Autism spectrum disorder (ASD) is a group of complex, neurological disorders that affect
early cognitive, social, and verbal development. Our understanding of ASD has vastly …

Inositol 1, 4, 5-trisphosphate (IP3) evokes Ca2+ release through IP3 receptors (IP3Rs) to
generate both local Ca2+ puffs arising from concerted openings of clustered IP3Rs and cell …

Background Autism spectrum disorder (ASD) covers a group of neurodevelopmental
disorders with complex genetic background. Several genetic mutations, epigenetic …

The spatial and temporal regulation of calcium signaling in neuronal growth cones is
essential for axon guidance. In growth cones, the endoplasmic reticulum (ER) is a significant …

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurological disorder that affects
premutation carriers with 55-200 CGG-expansion repeats (preCGG) in FMR1, presenting …