Nanoengineered immune niches for reprogramming the immunosuppressive tumor microenvironment and enhancing cancer immunotherapy

H Phuengkham, L Ren, IW Shin, YT Lim - Advanced Materials, 2019 - Wiley Online Library
Cancer immunotherapies that harness the body's immune system to combat tumors have
received extensive attention and become mainstream strategies for treating cancer. Despite …

Pharmacology of apocynin: a natural acetophenone

SR Savla, AP Laddha, YA Kulkarni - Drug metabolism reviews, 2021 - Taylor & Francis
Apocynin is a naturally occurring acetophenone, found in the roots of Apocynum
cannabinum and Picrorhiza kurroa. Various chemical and pharmaceutical modifications …

Intracellular Self‐Assembly Driven Nucleus‐Targeted Photo‐Immune Stimulator with Chromatin Decompaction Function for Robust Innate and Adaptive Antitumor …

X Zhao, K Zhang, Y Wang, W Jiang… - Advanced Functional …, 2022 - Wiley Online Library
Efficient nuclear DNA damage and release is highly recommended to improve the
photodynamic immunotherapy by eliciting innate immune response yet remains challenging …

PEG-b-PLA micelles and PLGA-b-PEG-b-PLGA sol–gels for drug delivery

H Cho, J Gao, GS Kwon - Journal of Controlled Release, 2016 - Elsevier
Abstract Poly (ethylene glycol)-block-poly (D, L-lactic acid)(PEG-b-PLA) micelles and poly
(D, L-lactic-co-glycolic acid)-block-polyethylene glycol)-block-poly (D, L-lactic-co-glycolic …

Synthesis, characterization, toxicity and morphology assessments of newly prepared microemulsion systems for delivery of valproic acid

S Sargazi, MR Ha**ezhad, M Barani, A Rahdar… - Journal of Molecular …, 2021 - Elsevier
Valproic acid (VPA), an anti-epileptic drug used to treat seizures, epilepsy, and
psychological disorders, has shown promising antitumor potential; however, the side effects …

Hyaluronic acid-coated solid lipid nanoparticles for targeted delivery of vorinostat to CD44 overexpressing cancer cells

TH Tran, JY Choi, T Ramasamy, DH Truong… - Carbohydrate …, 2014 - Elsevier
Hyaluronic acid (HA)-decorated solid lipid nanoparticles (SLNs) were developed for tumor-
targeted delivery of vorinostat (VRS), a histone deacetylase inhibitor. HA, a naturally …

Enhanced cellular uptake and cytotoxicity of vorinostat through encapsulation in TPGS-modified liposomes

MA Farooq, H **nyu, A Jabeen, A Ahsan… - Colloids and Surfaces B …, 2021 - Elsevier
Vorinostat (VOR) is known as one of the histone deacetylase inhibitors (HDACi) for cancer
treatment, and the FDA approves it for cutaneous T cell lymphoma therapy. Poor solubility …

Novel pH-responsive E-selectin targeting natural polysaccharides hybrid micelles for diabetic nephropathy

C Guo, M Cao, N Diao, W Wang, H Geng, Y Su… - … , Biology and Medicine, 2023 - Elsevier
Diabetic nephropathy (DN) is an important complication of diabetes and is the main cause of
end-stage renal disease. The pathogenesis of DN is complex, including glucose and lipid …

Biopharmaceutical and pharmacokinetic aspects of nanocarrier-mediated oral delivery of poorly soluble drugs

D Babadi, S Dadashzadeh, M Osouli… - Journal of Drug Delivery …, 2021 - Elsevier
Many new chemical entities have limited water solubility and therefore show low and/or
variable oral bioavailability. Among the various strategies to overcome this challenge …

Polyester nanoparticles delivering chemotherapeutics: Learning from the past and looking to the future to enhance their clinical impact in tumor therapy

G Longobardi, TL Moore, C Conte… - Wiley …, 2024 - Wiley Online Library
Polymeric nanoparticles (NPs), specifically those comprised of biodegradable and
biocompatible polyesters, have been heralded as a game‐changing drug delivery platform …