Abstract The KEAP1-NRF2-ARE signaling pathway plays a central role in mediating the
adaptive cellular stress response to oxidative and electrophilic chemicals. This canonical …

Per‐and poly‐fluoroalkyl substances (PFAS) encompass a large, heterogenous group of
chemicals of potential concern to human health and the environment. Based on information …

Researcher and media alarms have caused plastic debris to be perceived as a major threat
to humans and animals. However, although the waste of plastic in the environment is clearly …

Genotoxicity data are mainly interpreted in a qualitative way, which typically results in a
binary classification of chemical entities. For more than a decade, there has been a …

In silico toxicology is an emerging field. It gains increasing importance as research is aiming
to decrease the use of animal experiments as suggested in the 3R principles by Russell and …

An important goal in toxicology is the development of new ways to increase the speed,
accuracy, and applicability of chemical hazard and risk assessment approaches. A …

In conjunction with the second International Environmental Omics Symposium (iEOS)
conference, held at the University of Liverpool (United Kingdom) in September 2014, a …

Microplastics (MPs) exist widely in the environment and can enter the human body indirectly
through the food chain or directly through inhalation or ingestion. The primary organ that …

Toxicity testing and regulation of advanced materials at the nanoscale, ie nanosafety, is
challenged by the growing number of nanomaterials and their property variants requiring …

The quantitative adverse outcome pathway (qAOP) concept is gaining interest due to its
potential regulatory applications in chemical risk assessment. Even though an increasing …