Evolutionary pathways and trajectories in antibiotic resistance
Evolution is the hallmark of life. Descriptions of the evolution of microorganisms have
provided a wealth of information, but knowledge regarding “what happened” has precluded …
provided a wealth of information, but knowledge regarding “what happened” has precluded …
Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature
The last decade has seen a growing number of experiments aimed at systematically
map** the effects of mutations in different proteins, and of attempting to correlate their …
map** the effects of mutations in different proteins, and of attempting to correlate their …
Accurate measurement of the effects of all amino-acid mutations on influenza hemagglutinin
Influenza genes evolve mostly via point mutations, and so knowing the effect of every amino-
acid mutation provides information about evolutionary paths available to the virus. We and …
acid mutation provides information about evolutionary paths available to the virus. We and …
Inference of the distribution of selection coefficients for new nonsynonymous mutations using large samples
The distribution of fitness effects (DFE) has considerable importance in population genetics.
To date, estimates of the DFE come from studies using a small number of individuals. Thus …
To date, estimates of the DFE come from studies using a small number of individuals. Thus …
High‐throughput discovery of functional disordered regions: investigation of transactivation domains
CNJ Ravarani, TY Erkina, G De Baets… - Molecular Systems …, 2018 - embopress.org
Over 40% of proteins in any eukaryotic genome encode intrinsically disordered regions (IDR
s) that do not adopt defined tertiary structures. Certain IDR s perform critical functions, but …
s) that do not adopt defined tertiary structures. Certain IDR s perform critical functions, but …
Deconstruction of the Ras switching cycle through saturation mutagenesis
Ras proteins are highly conserved signaling molecules that exhibit regulated, nucleotide-
dependent switching between active and inactive states. The high conservation of Ras …
dependent switching between active and inactive states. The high conservation of Ras …
Systematic mutant analyses elucidate general and client-specific aspects of Hsp90 function
To probe the mechanism of the Hsp90 chaperone that is required for the maturation of many
signaling proteins in eukaryotes, we analyzed the effects of all individual amino acid …
signaling proteins in eukaryotes, we analyzed the effects of all individual amino acid …
Comprehensive fitness maps of Hsp90 show widespread environmental dependence
Gene-environment interactions have long been theorized to influence molecular evolution.
However, the environmental dependence of most mutations remains unknown. Using deep …
However, the environmental dependence of most mutations remains unknown. Using deep …
Experimental estimation of the effects of all amino-acid mutations to HIV's envelope protein on viral replication in cell culture
HK Haddox, AS Dingens, JD Bloom - PLoS pathogens, 2016 - journals.plos.org
HIV is notorious for its capacity to evade immunity and anti-viral drugs through rapid
sequence evolution. Knowledge of the functional effects of mutations to HIV is critical for …
sequence evolution. Knowledge of the functional effects of mutations to HIV is critical for …
Systematic map** of protein mutational space by prolonged drift reveals the deleterious effects of seemingly neutral mutations
L Rockah-Shmuel, Á Tóth-Petróczy… - PLoS computational …, 2015 - journals.plos.org
Systematic map**s of the effects of protein mutations are becoming increasingly popular.
Unexpectedly, these experiments often find that proteins are tolerant to most amino acid …
Unexpectedly, these experiments often find that proteins are tolerant to most amino acid …