Nonalcoholic fatty liver disease (NAFLD) prevalence in women is increasing worldwide.
Women of reproductive age have lower rates of NAFLD compared with men; however, this …

Fatty liver diseases can result from common metabolic diseases, as well as from xenobiotic
exposure and excessive alcohol use, all of which have been shown to exert toxic effects on …

Fatty liver disease is one of the major causes of morbidity and mortality worldwide. Fatty liver
includes non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis …

Background Few studies report the effects of tamoxifen intake and the occurrence of de novo
fatty liver and the deterioration of existing fatty liver. The aim of this study was to investigate …

Estrogen receptor α (ERα) plays a key role in the adaptive response of liver metabolism to
energy demands, especially in controlling lipid metabolism. Tamoxifen (TMX), a main drug …

Background Clinically, long-term use of tamoxifen (TAM) would lead to fatty liver disease in
breast cancer patients, especially obese women. However, the exact mechanism of TAM …

Cholesterol is crucial for cell survival and growth, and dysregulation of cholesterol
homeostasis has been linked to the development of cancer. The tumor microenvironment …

Fatty liver is considered to be the most common chronic liver disease with a high global
incidence, which can lead to cirrhosis and liver cancer in severe cases, and there is no …

Purpose Long-term estrogen inhibition may cause fatty liver disease (non-alcoholic fatty liver
disease; NAFLD) among other adverse conditions such as osteoporosis, climacteric …

Tamoxifen (TAM) is a life‐saving and cost‐effective drug widely used in the prevention and
treatment of breast cancer. However, the adverse effects of tamoxifen can lead to non …