Antimicrobial peptides: mechanisms of action and resistance

B Bechinger, SU Gorr - Journal of dental research, 2017 - journals.sagepub.com
More than 40 antimicrobial peptides and proteins (AMPs) are expressed in the oral cavity.
These AMPs have been organized into 6 functional groups, 1 of which, cationic AMPs, has …

[HTML][HTML] Reassessing the host defense peptide landscape

EF Haney, SK Straus, REW Hancock - Frontiers in chemistry, 2019 - frontiersin.org
Current research has demonstrated that small cationic amphipathic peptides have strong
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …

[HTML][HTML] Gram-positive bacterial cell envelopes: The impact on the activity of antimicrobial peptides

N Malanovic, K Lohner - Biochimica et Biophysica Acta (BBA) …, 2016 - Elsevier
A number of cationic antimicrobial peptides, effectors of innate immunity, are supposed to
act at the cytoplasmic membrane leading to permeabilization and eventually membrane …

Antimicrobial peptides: interaction with model and biological membranes and synergism with chemical antibiotics

A Hollmann, M Martinez, P Maturana… - Frontiers in …, 2018 - frontiersin.org
Antimicrobial peptides (AMPs) are promising novel antibiotics since they have shown
antimicrobial activity against a wide range of bacterial species, including multiresistant …

Antimicrobial peptides targeting gram-positive bacteria

N Malanovic, K Lohner - Pharmaceuticals, 2016 - mdpi.com
Antimicrobial peptides (AMPs) have remarkably different structures as well as biological
activity profiles, whereupon most of these peptides are supposed to kill bacteria via …

Antimicrobial susceptibility testing of antimicrobial peptides to better predict efficacy

DK Mercer, MDT Torres, SS Duay, E Lovie… - Frontiers in cellular …, 2020 - frontiersin.org
During the development of antimicrobial peptides (AMP) as potential therapeutics,
antimicrobial susceptibility testing (AST) stands as an essential part of the process in …

Peptides and peptidomimetics for antimicrobial drug design

B Mojsoska, H Jenssen - Pharmaceuticals, 2015 - mdpi.com
The purpose of this paper is to introduce and highlight a few classes of traditional
antimicrobial peptides with a focus on structure-activity relationship studies. After first …

Clinical applications of antimicrobial peptides (AMPs): where do we stand now?

M Divyashree, MK Mani, D Reddy… - Protein and peptide …, 2020 - ingentaconnect.com
In this era of multi-drug resistance (MDR), antimicrobial peptides (AMPs) are one of the most
promising classes of potential drug candidates to combat communicable as well as …

Inoculum effect of antimicrobial peptides

MR Loffredo, F Savini, S Bobone… - Proceedings of the …, 2021 - National Acad Sciences
The activity of many antibiotics depends on the initial density of cells used in bacterial
growth inhibition assays. This phenomenon, termed the inoculum effect, can have important …

Nanotechnology-based delivery systems for antimicrobial peptides

AO Fadaka, NRS Sibuyi, AM Madiehe, M Meyer - Pharmaceutics, 2021 - mdpi.com
Antimicrobial resistance (AMR) is a significant threat to global health. The conventional
antibiotic pool has been depleted, forcing the investigation of novel and alternative …