Abstract CD95 (APO-1/Fas) is a prototype death receptor characterized by the presence of
an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the …

Immune cell functions are regulated by co-inhibitory and co-stimulatory receptors. The first
two generations of cancer immunotherapy agents consist primarily of antagonist antibodies …

A conserved domain in the extracellular region of the 60-and 80-kilodalton tumor necrosis
factor receptors (TNFRs) was identified that mediates specific ligand-independent assembly …

The tumor necrosis factor (TNF) ligand and receptor superfamilies play an important role in
cell proliferation, survival, and death. Stimulating or inhibiting TNF superfamily signaling …

Heterozygous mutations encoding abnormal forms of the death receptor Fas dominantly
interfere with Fas-induced lymphocyte apoptosis in human autoimmune lymphoproliferative …

Apoptosis ligand 2 tumor necrosis factor (TNF)-related apoptosis-inducing ligand
(Apo2L/TRAIL) belongs to a small subset of proapoptotic protein ligands in the TNF …

Virus infection can trigger extrinsic apoptosis. Cell-surface death receptors of the tumor
necrosis factor family mediate this process. They either assist persistent viral infection or …

Originally identified as a cell surface receptor that triggered the death of lymphocytes and
tumor cells, it is now recognized that Fas (also known as CD95 or Apo-1) has distinct …

Binding of either ligand or agonistic antibodies to the death receptor CD95 (APO-1/Fas)
induces the formation of the death-inducing signaling complex (DISC). We now show that …

From the beginning of research on receptors of the tumor necrosis factor (TNF) receptor
superfamily (TNFRSF), agonistic antibodies have been used to stimulate TNFRSF receptors …