Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology

H Sies, VV Belousov, NS Chandel, MJ Davies… - … reviews Molecular cell …, 2022 - nature.com
Abstract 'Reactive oxygen species'(ROS) is a generic term that defines a wide variety of
oxidant molecules with vastly different properties and biological functions that range from …

New photosensitizers for photodynamic therapy

H Abrahamse, MR Hamblin - Biochemical Journal, 2016 - portlandpress.com
Photodynamic therapy (PDT) was discovered more than 100 years ago, and has since
become a well-studied therapy for cancer and various non-malignant diseases including …

Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy

Z Zhou, J Song, L Nie, X Chen - Chemical society reviews, 2016 - pubs.rsc.org
The reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the
efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of …

Upconversion dual-photosensitizer–expressing bacteria for near-infrared monochromatically excitable synergistic phototherapy

M Chen, Q Han, M Zhang, Y Liu, L Wang, F Yang… - Science …, 2024 - science.org
Synergistic phototherapy stands for superior treatment prospects than a single
phototherapeutic modality. However, the combined photosensitizers often suffer from …

Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway

J Zhang, CM Simpson, J Berner, HB Chong, J Fang… - Cell, 2023 - cell.com
Multiple anticancer drugs have been proposed to cause cell death, in part, by increasing the
steady-state levels of cellular reactive oxygen species (ROS). However, for most of these …

A designed photoenzyme for enantioselective [2+ 2] cycloadditions

JS Trimble, R Crawshaw, FJ Hardy, CW Levy… - Nature, 2022 - nature.com
The ability to program new modes of catalysis into proteins would allow the development of
enzyme families with functions beyond those found in nature. To this end, genetic code …

The fluorescent toolbox for assessing protein location and function

BNG Giepmans, SR Adams, MH Ellisman, RY Tsien - science, 2006 - science.org
Advances in molecular biology, organic chemistry, and materials science have recently
created several new classes of fluorescent probes for imaging in cell biology. Here we …

The 4D nucleome project

J Dekker, AS Belmont, M Guttman, VO Leshyk, JT Lis… - Nature, 2017 - nature.com
Abstract The 4D Nucleome Network aims to develop and apply approaches to map the
structure and dynamics of the human and mouse genomes in space and time with the goal …

Fluorescent proteins and genetically encoded biosensors

M Wang, Y Da, Y Tian - Chemical Society Reviews, 2023 - pubs.rsc.org
The genetically encoded fluorescent sensors convert chemical and physical signals into
light. They are powerful tools for the visualisation of physiological processes in living cells …

Fluorescent proteins and their applications in imaging living cells and tissues

DM Chudakov, MV Matz, S Lukyanov… - Physiological …, 2010 - journals.physiology.org
Green fluorescent protein (GFP) from the jellyfish Aequorea victoria and its homologs from
diverse marine animals are widely used as universal genetically encoded fluorescent labels …