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Defining roles of specific reactive oxygen species (ROS) in cell biology and physiology
Abstract 'Reactive oxygen species'(ROS) is a generic term that defines a wide variety of
oxidant molecules with vastly different properties and biological functions that range from …
oxidant molecules with vastly different properties and biological functions that range from …
Fluorescent proteins and genetically encoded biosensors
M Wang, Y Da, Y Tian - Chemical Society Reviews, 2023 - pubs.rsc.org
The genetically encoded fluorescent sensors convert chemical and physical signals into
light. They are powerful tools for the visualisation of physiological processes in living cells …
light. They are powerful tools for the visualisation of physiological processes in living cells …
Upconversion dual-photosensitizer–expressing bacteria for near-infrared monochromatically excitable synergistic phototherapy
M Chen, Q Han, M Zhang, Y Liu, L Wang, F Yang… - Science …, 2024 - science.org
Synergistic phototherapy stands for superior treatment prospects than a single
phototherapeutic modality. However, the combined photosensitizers often suffer from …
phototherapeutic modality. However, the combined photosensitizers often suffer from …
Systematic identification of anticancer drug targets reveals a nucleus-to-mitochondria ROS-sensing pathway
J Zhang, CM Simpson, J Berner, HB Chong, J Fang… - Cell, 2023 - cell.com
Multiple anticancer drugs have been proposed to cause cell death, in part, by increasing the
steady-state levels of cellular reactive oxygen species (ROS). However, for most of these …
steady-state levels of cellular reactive oxygen species (ROS). However, for most of these …
A designed photoenzyme for enantioselective [2+ 2] cycloadditions
The ability to program new modes of catalysis into proteins would allow the development of
enzyme families with functions beyond those found in nature. To this end, genetic code …
enzyme families with functions beyond those found in nature. To this end, genetic code …
Tailoring photosensitive ROS for advanced photodynamic therapy
Photodynamic therapy (PDT) has been considered a noninvasive and cost-effective
modality for tumor treatment. However, the complexity of tumor microenvironments poses …
modality for tumor treatment. However, the complexity of tumor microenvironments poses …
Full-coverage regulations of autophagy by ROS: from induction to maturation
Macroautophagy/autophagy is an evolutionarily well-conserved recycling process in
response to stress conditions, including a burst of reactive oxygen species (ROS) …
response to stress conditions, including a burst of reactive oxygen species (ROS) …
GSH/pH Dual Activatable Cross‐linked and Fluorinated PEI for Cancer Gene Therapy Through Endogenous Iron De‐Hijacking and in Situ ROS Amplification
Ferroptosis‐related cancer therapy is limited by insufficient Fe2+/Fe3+ redox pair and
hydrogen peroxide (H2O2) for producing lethal hydroxyl radicals (· OH). Although …
hydrogen peroxide (H2O2) for producing lethal hydroxyl radicals (· OH). Although …
Reactive oxygen species generating systems meeting challenges of photodynamic cancer therapy
The reactive oxygen species (ROS)-mediated mechanism is the major cause underlying the
efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of …
efficacy of photodynamic therapy (PDT). The PDT procedure is based on the cascade of …
New photosensitizers for photodynamic therapy
H Abrahamse, MR Hamblin - Biochemical Journal, 2016 - portlandpress.com
Photodynamic therapy (PDT) was discovered more than 100 years ago, and has since
become a well-studied therapy for cancer and various non-malignant diseases including …
become a well-studied therapy for cancer and various non-malignant diseases including …