Antigen presentation is in the center of the immune system, both in host defense against
pathogens, but also when the system is unbalanced and autoimmune diseases like multiple …

Simple Summary Immunoproteasome plays a key role in the generation of antigenic
peptides. Immune checkpoints therapy is a front-line treatment of advanced/metastatic …

Intrinsically disordered myelin basic protein (MBP) is one of the key autoantigens in
autoimmune neurodegeneration and multiple sclerosis particularly. MBP is highly positively …

The abnormal accumulation of neurotoxic proteins is the typical hallmark of various age-
related neurodegenerative disorders (NDDs), including Alzheimer's disease, Parkinson's …

Multiple sclerosis is an autoimmune disease of the CNS in which both genetic and
environmental factors are involved. Genome-wide association studies revealed more than …

Alzheimer's disease (AD) is characterized by deficits in olfaction and olfactory pathology
preceding diagnosis of dementia. Here we analyzed differential gene and protein …

Recent findings indicate that the ubiquitin–proteasome system is involved in the
pathogenesis of cancer as well as autoimmune and several neurodegenerative diseases …

Multiple sclerosis (MS) is an autoimmune, neurodegenerative disease associated with the
central nervous system (CNS). Autoimmunity is caused by an abnormal immune response to …

In the middle of the 20th century, it was postulated that degradation of intracellular proteins
is a stochastic process. More than fifty years of intense studies have finally proven that …

Immunoproteasomes are alternative forms of proteasomes specialized in the generation of
MHC class I antigenic peptides and important for efficient cytokine production. We have …