Soft connective tissues at steady state are dynamic; resident cells continually read
environmental cues and respond to them to promote homeostasis, including maintenance of …

Myofibroblasts, and the extracellular matrix (ECM) in which they reside, are critical
components of wound healing and fibrosis. The ECM, traditionally viewed as the structural …

The term matricellular proteins describes a family of structurally unrelated extracellular
macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue …

Chronic liver disease when accompanied by underlying fibrosis, is characterized by an
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …

The factors responsible for maintaining persistent organ fibrosis in systemic sclerosis (SSc)
are not known but emerging evidence implicates toll-like receptors (TLRs) in the …

The extracellular matrix molecule tenascin-C is highly expressed during embryonic
development, tissue repair and in pathological situations such as chronic inflammation and …

Tenascin-C is an extracellular matrix glycoprotein that is specifically and transiently
expressed upon tissue injury. Upon tissue damage, tenascin-C plays a multitude of different …

Tenascin-C is a large, multimodular, extracellular matrix glycoprotein that exhibits a very
restricted pattern of expression but an enormously diverse range of functions. Here, we …

For decades tumors have been recognized as “wounds that do not heal.” Besides the
commonalities that tumors and wounded tissues share, the process of wound healing also …

The ovarian microenvironment becomes fibrotic and stiff with age, in part due to increased
collagen and decreased hyaluronan. However, the extracellular matrix (ECM) is a complex …