Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity

H Cao, L Duan, Y Zhang, J Cao, K Zhang - Signal transduction and …, 2021 - nature.com
Hydrogel is a type of versatile platform with various biomedical applications after rational
structure and functional design that leverages on material engineering to modulate its …

Harnessing the potential of hydrogels for advanced therapeutic applications: Current achievements and future directions

P Lu, D Ruan, M Huang, M Tian, K Zhu… - Signal transduction and …, 2024 - nature.com
The applications of hydrogels have expanded significantly due to their versatile, highly
tunable properties and breakthroughs in biomaterial technologies. In this review, we cover …

Engineered hydrogels for mechanobiology

U Blache, EM Ford, B Ha, L Rijns… - Nature Reviews …, 2022 - nature.com
Cells' local mechanical environment can be as important in guiding cellular responses as
many well-characterized biochemical cues. Hydrogels that mimic the native extracellular …

Depletion of tumor associated macrophages enhances local and systemic platelet-mediated anti-PD-1 delivery for post-surgery tumor recurrence treatment

Z Li, Y Ding, J Liu, J Wang, F Mo, Y Wang… - Nature …, 2022 - nature.com
Immunosuppressive cells residing in the tumor microenvironment, especially tumor
associated macrophages (TAMs), hinder the infiltration and activation of T cells, limiting the …

Precision cancer sono-immunotherapy using deep-tissue activatable semiconducting polymer immunomodulatory nanoparticles

J Li, Y Luo, Z Zeng, D Cui, J Huang, C Xu, L Li… - Nature …, 2022 - nature.com
Nanomedicine holds promise to enhance cancer immunotherapy; however, its potential to
elicit highly specific anti-tumor immunity without compromising immune tolerance has yet to …

Biomedical polymers: synthesis, properties, and applications

WH Chen, QW Chen, Q Chen, C Cui, S Duan… - Science China …, 2022 - Springer
Biomedical polymers have been extensively developed for promising applications in a lot of
biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis …

Delivery of CAR-T cells in a transient injectable stimulatory hydrogel niche improves treatment of solid tumors

AK Grosskopf, L Labanieh, DD Klysz, GA Roth, P Xu… - Science …, 2022 - science.org
Adoptive cell therapy (ACT) has proven to be highly effective in treating blood cancers, but
traditional approaches to ACT are poorly effective in treating solid tumors observed …

Boosting checkpoint immunotherapy with biomaterials

L Liu, Y Pan, C Zhao, P Huang, X Chen, L Rao - ACS nano, 2023 - ACS Publications
The immune checkpoint blockade (ICB) therapy has revolutionized the field of cancer
treatment, while low response rates and systemic toxicity limit its clinical outcomes. With the …

Amplification of activated near-infrared afterglow luminescence by introducing twisted molecular geometry for understanding neutrophil-involved diseases

C Chen, H Gao, H Ou, RTK Kwok, Y Tang… - Journal of the …, 2022 - ACS Publications
Understanding the mechanism and progression of neutrophil-involved diseases (eg, acute
inflammation) is of great importance. However, current available analytical methods neither …

Recent advances in overcoming barriers to cell‐based delivery systems for cancer immunotherapy

Y Ding, Y Wang, Q Hu - Exploration, 2022 - Wiley Online Library
Immunotherapy strategies that use cell‐based delivery systems have sparked much interest
in the treatment of malignancies, owing to their high biocompatibility, excellent tumor …