Melatonin is an immune modulator that displays both pro‐and anti‐inflammatory properties.
Proinflammatory actions, which are well documented by many studies in isolated cells or …

Background: Melatonin synchronizes central but also peripheral oscillators (fetal adrenal
gland, pancreas, liver, kidney, heart, lung, fat, gut, etc.), allowing temporal organization of …

The skin, being the largest organ in the human body, is exposed to the environment and
suffers from both intrinsic and extrinsic aging factors. The skin aging process is …

Melatonin is an ancient antioxidant. After its initial development in bacteria, it has been
retained throughout evolution such that it may be or may have been present in every species …

Aging and various age-related diseases are associated with reductions in melatonin
secretion, proinflammatory changes in the immune system, a deteriorating circadian system …

There is highly credible evidence that melatonin mitigates cancer at the initiation,
progression and metastasis phases. In many cases, the molecular mechanisms …

Oxidative stress (OS) represents a threat to the chemical integrity of biomolecules including
lipids, proteins, and DNA. The associated molecular damage frequently results in serious …

Endogenous melatonin is synthesized from tryptophan via 5-hydroxytryptamine. It is
considered an indoleamine from a biochemical point of view because the melatonin …

Abstract Melatonin (N‐acetyl‐5‐methoxytryptamine), an indoleamine produced in many
organs including the pineal gland, was initially characterized as a hormone primarily …

Melatonin is a small, highly conserved indole with numerous receptor-mediated and
receptor-independent actions. Receptor-dependent functions include circadian rhythm …