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Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?
SE Engelen, AJB Robinson, YX Zurke… - Nature Reviews …, 2022 - nature.com
Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …
formation of plaques containing lipid, connective tissue and immune cells in the intima of …
Interplay between inflammation and thrombosis in cardiovascular pathology
Thrombosis is the most feared complication of cardiovascular diseases and a main cause of
death worldwide, making it a major health-care challenge. Platelets and the coagulation …
death worldwide, making it a major health-care challenge. Platelets and the coagulation …
Neutrophils in tissue injury and repair
J Wang - Cell and tissue research, 2018 - Springer
As one of the first defenders of innate immune response, neutrophils make a rapid and
robust response against infection or harmful agents. While traditionally regarded as suicidal …
robust response against infection or harmful agents. While traditionally regarded as suicidal …
More friend than foe: the emerging role of neutrophils in tissue repair
Neutrophils are the most abundant immune cells in humans and serve as first responders to
a myriad of host perturbations. Equipped with a plethora of antimicrobial molecules …
a myriad of host perturbations. Equipped with a plethora of antimicrobial molecules …
Neutrophils as protagonists and targets in chronic inflammation
Traditionally, neutrophils have been acknowledged to be the first immune cells that are
recruited to an inflamed tissue and have mainly been considered in the context of acute …
recruited to an inflamed tissue and have mainly been considered in the context of acute …
Neutrophil recruitment and function in health and inflammation
Neutrophils have traditionally been thought of as simple foot soldiers of the innate immune
system with a restricted set of pro-inflammatory functions. More recently, it has become …
system with a restricted set of pro-inflammatory functions. More recently, it has become …
Biological roles of neutrophil-derived granule proteins and cytokines
Neutrophils, the most abundant white blood cells in human circulation, entertain intense
interactions with other leukocyte subsets, platelets, and stromal cells. Molecularly, such …
interactions with other leukocyte subsets, platelets, and stromal cells. Molecularly, such …
Targeting neutrophils for promoting the resolution of inflammation
JG Filep - Frontiers in immunology, 2022 - frontiersin.org
Acute inflammation is a localized and self-limited innate host-defense mechanism against
invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in …
invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in …
Diverse novel functions of neutrophils in immunity, inflammation, and beyond
Neutrophils have long been considered simple suicide killers at the bottom of the hierarchy
of the immune response. That view began to change 10–20 yr ago, when the sophisticated …
of the immune response. That view began to change 10–20 yr ago, when the sophisticated …
[HTML][HTML] Role of neutrophils in cardiac injury and repair following myocardial infarction
Y Ma - Cells, 2021 - mdpi.com
Neutrophils are first-line responders of the innate immune system. Following myocardial
infarction (MI), neutrophils are quickly recruited to the ischemic region, where they initiate …
infarction (MI), neutrophils are quickly recruited to the ischemic region, where they initiate …