Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury
Essential metals are crucial for the maintenance of cell homeostasis. Among the 23
elements that have known physiological functions in humans, 12 are metals, including iron …
elements that have known physiological functions in humans, 12 are metals, including iron …
Oxidative stress in MeHg-induced neurotoxicity
Methylmercury (MeHg) is an environmental toxicant that leads to long-lasting neurological
and developmental deficits in animals and humans. Although the molecular mechanisms …
and developmental deficits in animals and humans. Although the molecular mechanisms …
[HTML][HTML] Recommendation on test readiness criteria for new approach methods (NAM) in toxicology: exemplified for developmental neurotoxicity (DNT)
A Bal-Price, HT Hogberg, KM Crofton, M Daneshian… - Altex, 2018 - ncbi.nlm.nih.gov
Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …
such new approach methods (NAMs) in a regulatory context, criteria to define their …
Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection …
There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard
posed by industrial and environmental chemicals. New testing approaches will most likely …
posed by industrial and environmental chemicals. New testing approaches will most likely …
Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach
Developmental neurotoxicity (DNT) and many forms of reproductive toxicity (RT) often
manifest themselves in functional deficits that are not necessarily based on cell death, but …
manifest themselves in functional deficits that are not necessarily based on cell death, but …
In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities
Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard
assessment. Since the interpretation of animal data and their extrapolation to man is …
assessment. Since the interpretation of animal data and their extrapolation to man is …
[HTML][HTML] Food for Thought…: Developmental Neurotoxicity–Challenges in the 21st Century and In Vitro Opportunities
In recent years neurodevelopmental problems in children have increased at a rate that
suggests lifestyle factors and chemical exposures as likely contributors. When …
suggests lifestyle factors and chemical exposures as likely contributors. When …
Toxicity of organic and inorganic mercury species in differentiated human neurons and human astrocytes
H Lohren, L Blagojevic, R Fitkau, F Ebert… - Journal of Trace …, 2015 - Elsevier
Organic mercury (Hg) species exert their toxicity primarily in the central nervous system. The
food relevant Hg species methylmercury (MeHg) has been frequently studied regarding its …
food relevant Hg species methylmercury (MeHg) has been frequently studied regarding its …
[HTML][HTML] A high-throughput approach to identify specific neurotoxicants/developmental toxicants in human neuronal cell function assays
J Delp, S Gutbier, S Klima, L Hoelting, K Pinto-Gil… - Altex, 2018 - ncbi.nlm.nih.gov
The (developmental) neurotoxicity hazard is still unknown for most chemicals. Establishing a
test battery covering most of the relevant adverse outcome pathways may close this gap …
test battery covering most of the relevant adverse outcome pathways may close this gap …
A 3-dimensional human embryonic stem cell (hESC)-derived model to detect developmental neurotoxicity of nanoparticles
L Hoelting, B Scheinhardt, O Bondarenko… - Archives of …, 2013 - Springer
Nanoparticles (NPs) have been shown to accumulate in organs, cross the blood–brain
barrier and placenta, and have the potential to elicit developmental neurotoxicity (DNT) …
barrier and placenta, and have the potential to elicit developmental neurotoxicity (DNT) …