Emerging roles of ATG proteins and membrane lipids in autophagosome formation
T Nishimura, SA Tooze - Cell discovery, 2020 - nature.com
Autophagosome biogenesis is a dynamic membrane event, which is executed by the
sequential function of autophagy-related (ATG) proteins. Upon autophagy induction, a cup …
sequential function of autophagy-related (ATG) proteins. Upon autophagy induction, a cup …
The role of Atg proteins in autophagosome formation
N Mizushima, T Yoshimori… - Annual review of cell and …, 2011 - annualreviews.org
Macroautophagy is mediated by a unique organelle, the autophagosome, which encloses a
portion of cytoplasm for delivery to the lysosome. Autophagosome formation is dynamically …
portion of cytoplasm for delivery to the lysosome. Autophagosome formation is dynamically …
Mammalian autophagy: core molecular machinery and signaling regulation
Z Yang, DJ Klionsky - Current opinion in cell biology, 2010 - Elsevier
Autophagy, a cellular catabolic pathway, is evolutionarily conserved from yeast to mammals.
Central to this process is the formation of autophagosomes, double-membrane vesicles …
Central to this process is the formation of autophagosomes, double-membrane vesicles …
Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins
E Itakura, N Mizushima - Autophagy, 2010 - Taylor & Francis
Autophagy is an intracellular degradation process, through which cytosolic materials are
delivered to the lysosome. Despite recent identification of many autophagy-related genes …
delivered to the lysosome. Despite recent identification of many autophagy-related genes …
MicroRNA-21 promotes fibrosis of the kidney by silencing metabolic pathways
BN Chau, C **n, J Hartner, S Ren… - Science translational …, 2012 - science.org
Scarring of the kidney is a major public health concern, directly promoting loss of kidney
function. To understand the role of microRNA (miRNA) in the progression of kidney scarring …
function. To understand the role of microRNA (miRNA) in the progression of kidney scarring …
TMEM 41B is a novel regulator of autophagy and lipid mobilization
F Moretti, P Bergman, S Dodgson, D Marcellin… - EMBO …, 2018 - embopress.org
Autophagy maintains cellular homeostasis by targeting damaged organelles, pathogens, or
misfolded protein aggregates for lysosomal degradation. The autophagic process is initiated …
misfolded protein aggregates for lysosomal degradation. The autophagic process is initiated …
[HTML][HTML] Lack of VMP1 impairs hepatic lipoprotein secretion and promotes non-alcoholic steatohepatitis
Background & Aims Vacuole membrane protein 1 (VMP1) is an endoplasmic reticulum (ER)
transmembrane protein that regulates the formation of autophagosomes and lipid droplets …
transmembrane protein that regulates the formation of autophagosomes and lipid droplets …
CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor
The power of forward genetics in yeast is the foundation on which the field of autophagy
research firmly stands. Complementary work on autophagy in higher eukaryotes has …
research firmly stands. Complementary work on autophagy in higher eukaryotes has …
Vesicular trafficking and autophagosome formation
A Longatti, SA Tooze - Cell Death & Differentiation, 2009 - nature.com
The source of the autophagosome membrane, and the formation of the autophagosome
remain the most important questions for understanding autophagy. Fundamentally, the …
remain the most important questions for understanding autophagy. Fundamentally, the …
Dictyostelium discoideum—a model for many reasons
SJ Annesley, PR Fisher - Molecular and cellular biochemistry, 2009 - Springer
The social amoeba or cellular slime mould Dictyostelium discoideum is a “professional”
phagocyte that has long been recognized for its value as a biomedical model organism …
phagocyte that has long been recognized for its value as a biomedical model organism …