Obesity is an epidemic disease characterized by chronic low-grade inflammation associated
with a dysfunctional fat mass. Adipose tissue is now considered an extremely active …

Osteoarthritis (OA) is a widespread clinical disease characterized by cartilage degeneration
in middle-aged and elderly people. Currently, there is no effective treatment for OA apart …

Cellular senescence is the inability of cells to proliferate, which has both beneficial and
detrimental effects on tissue development and homeostasis. Chronic accumulation of …

Tissue engineering has been a promising field of research, offering hope for bridging the
gap between organ shortage and transplantation needs. However, building three …

Articular cartilage is a physiologically non-self-renewing avascular tissue with a singular cell
type, the chondrocyte, which functions as the load-bearing surface of the arthrodial joint …

Recent advances in bioprinting have granted tissue engineers the ability to assemble
biomaterials, cells and signaling molecules into anatomically relevant functional tissues or …

Ageing processes play a major contributing role for the development of Osteoarthritis (OA).
This prototypic degenerative condition of ageing is the most common form of arthritis and is …

Osteoarthritis (OA) is a common chronic disease and a significant health concern that needs
to be urgently solved. OA affects the cartilage and entire joint tissues, including the …

Excessive joint surface loadings, either single (acute impact event) or repetitive (cumulative
contact stress), can cause the clinical syndrome of osteoarthritis (OA). Despite advances in …

Current cell-based repair strategies have proven unsuccessful for treating cartilage defects
and osteoarthritic lesions, consequently advances in innovative therapeutics are required …